ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1657724
Associations of triglyceride-glucose (TYG) index with N-Terminal Pro-B-Type Natriuretic Peptide and mortality in middle-aged and elderly individuals
Provisionally accepted
- 1Nanjing University of Chinese Medicine, Nanjing, China
- 2Jiangsu Province Hospital of Chinese Medicine, Nanjing, China
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Background: The triglyceride-glucose (TYG) index is a simple marker for insulin resistance (IR). However, its relationship with elevated NT-proBNP levels is not well understood in middle-aged and elderly individuals without known cardiovascular diseases (CVD). Methods: The study cohort data were derived from National Health and Nutrition Examination Survey (NHANES) and inpatients of the Department of Cardiology at Jiangsu Provincial Hospital of Traditional Chinese Medicine (JSHTCM). Multivariable logistic regression was employed to assess the relationship between the TYG index and elevated NT-proBNP. Multivariable Cox proportional hazards models were used to estimate the adjusted risk ratio of the TYG index for all-cause mortality. Furthermore, restricted cubic spline (RCS) plots were generated to visually represent the linear or non-linear relationships between the TYG index and elevated NT-proBNP as well as all-cause mortality. Results: The age-standardized prevalence of elevated NT-proBNP among middle-aged and elderly individuals was 29.21% in females and 17.08% in males. A negative correlation was observed between the TYG index and elevated NT-proBNP, study cohort 1: [T3 vs T1: OR (95% CI): 0.73 (0.55, 0.96), p for trend= 0.027]; study cohort 2: [β (95% CI): -37.58 (-59.11, -16.06), p for trend = 0.002]. Each unit increase in the TYG index is correlated with a 25% increase in the adjusted risk of all-cause mortality [HR (95% CI): 1.25 (1.08, 1.44), p = 0.003]. The RCS plots supported the multivariate regression model findings. Conclusions: The TYG index level is negatively correlated with the incidence of elevated NT-proBNP and is associated with all-cause mortality, regardless of the presence of elevated NT-proBNP.
Keywords: TyG index, elevated NT-proBNP, All-cause mortality, Middle-aged and elderly, Population study
Received: 01 Jul 2025; Accepted: 03 Sep 2025.
Copyright: © 2025 Xie, Shen, Jianghong, Lv, Sun, Yu, Chen and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaohu Chen, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China
Shuhua Tang, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China
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