ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1658272
This article is part of the Research TopicTechnologies for Diabetes, volume IIIView all 7 articles
Effect of short-term intensive insulin pump therapy on serum Endotrophin levels in patients with newly diagnosed type 2 diabetes
Provisionally accepted
- 1Department of Endocrinology, Huai'an Second People's Hospital, Huaian, China
- 2Department of General Medicine, Huai'an Second People's Hospital, Huaian, China
- 3Medical Examination Center, Huai'an Second People's Hospital, Huaian, China
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Objective To investigate the effect of short-term intensive insulin (STII) pump therapy on serum endotrophin (ETP) levels in patients with newly diagnosed type 2 diabetes, examine the relationship between serum ETP levels and insulin resistance (IR). Subjects and methods Our study recruited 40 patients with newly diagnosed type 2 diabetes and 40 healthy controls. First, we compared the serum ETP levels between patients with newly diagnosed type 2 diabetes and controls. Second, 40 patients with newly diagnosed type 2 diabetes underwent two weeks of STII pump therapy. Results Higher serum ETP levels were observed in patients with newly diagnosed type 2 diabetes compared to controls. After 2 weeks of STII pump therapy, serum ETP levels significantly attenuated in patients with newly diagnosed type 2 diabetes. Both before and after treatment, serum ETP exhibited a significant positive correlation with homeostasis model 2 assessment of IR (HOMA2-IR). Multiple linear regression analysis revealed that changes in ETP levels (δ-ETP) were independently associated with changes in HOMA2-IR (δ-HOMA2-IR). Conclusions Serum ETP serves as a risk factor for type 2 diabetes and correlates with insulin resistance index. STII contributed to reducing the heightened inflammatory response in individuals with type 2 diabetes.
Keywords: endotrophin, type 2 diabetes, short‐term intensive insulin pump therapy, Insulin Resistance, Inflammation
Received: 02 Jul 2025; Accepted: 23 Sep 2025.
Copyright: © 2025 Li, Gui, Weng, Xun, Yu, xiang, Qi, Wang and Bai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Feng Bai, jiefu6887579@163.com
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