ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1666563
This article is part of the Research TopicDiabetes Complications: Navigating Challenges and Unveiling New SolutionsView all 13 articles
Association Between the Triglyceride-Glucose Index and Hyperuricemia in Patients with Type 2 Diabetes Mellitus
Provisionally accepted
- 1Department of Pharmacy, Nanjing Luhe People’s Hospital, Nanjing, China
- 2Department of Pharmacy, Nanjing Luhe People’s Hospital, Yangzhou University, Nanjing 211500, China, Nanjing, China
- 3Public Experimental Platform, China Pharmaceutical University, Nanjing, 211198, China., Nanjing, China
- 4Department of General surgery, Nanjing Luhe People’s Hospital, Yangzhou University., Nanjing, China
- 5Department of Pharmacy, Nanjing Luhe People’s Hospital, Yangzhou University, Nanjing, China
- 6Department of Central Laboratory, Nanjing Luhe People’s Hospital, Yangzhou University, Nanjing, China
- 7Department of Endocrinology, Nanjing Luhe People’s Hospital, Yangzhou University, Nanjing, China
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Aim: This cross-sectional study investigated the relationship between the triglyceride-glucose (TyG: A surrogate marker for assessing insulin resistance.) index and hyperuricemia (HUA: Metabolic diseases caused by purine metabolism disorders.) risk in Chinese patients with type 2 diabetes mellitus (T2DM). Methods: From January 2021 to December 2023, T2DM patients were enrolled from Luhe District People's Hospital in Nanjing. Participants were stratified by TyG index quartiles. Logistic regression and restricted cubic spline (RCS) analyses assessed the TyG-HUA association. Results: This study included 996 participants with type 2 diabetes, with a male predominance of 54.82%, a mean age of 60.39 years, and a median TyG index of 7.63. Compared to the lowest TyG quartile, the highest quartile exhibited a 4.23-fold (95% CI: 1.46 ~ 12.24, P value = 0.008) increased HUA risk. Restricted cubic spline analysis revealed a nonlinear relationship between the TyG index and HUA (nonlinear P value = 0.044). As the TyG level increased, the risk of HUA initially rose and then showed a downward trend (P for TyG = 0.008). Conclusions: Elevated TyG index independently predicts HUA risk in T2DM patients. Early metabolic intervention may mitigate HUA-related cardiovascular morbidity and mortality.
Keywords: TyG index, Hyperuricemia, type 2 diabetes mellitus, statistical analysis, RCS
Received: 15 Jul 2025; Accepted: 25 Sep 2025.
Copyright: © 2025 Sun, Qian, Li, Chen, Zhang, Zhao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xu Sun, sunxu127@126.com
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