ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1668064
This article is part of the Research TopicCardiovascular Risks in Cardiovascular-Kidney-Metabolic Syndrome: Mechanisms and TherapiesView all articles
The Relationship Between Albumin-Corrected Anion Gap and Hyperuricemia and Its Role in Cardiovascular Risk Assessment: Mediation Effect Analysis of Triglycerides and Non-High-Density Lipoproteins
Provisionally accepted
- 1Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China
- 2The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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Background: This study examines the relationship between Albumin-Corrected Anion Gap (ACAG) and hyperuricemia (HUA), as well as its potential mechanisms linking HUA to cardiovascular diseases. While HUA is associated with cardiovascular conditions, whether it is an independent risk factor remains unclear. ACAG, an indicator of acid-base balance, has prognostic value in cardiovascular outcomes, but its relationship with HUA has not been explored. Methods: Data from 4,588 adults who visited Guangdong Provincial Hospital of Chinese Medicine between January and December 2023 were analyzed. HUA was defined as a serum uric acid (SUA) level >420 μmol/L, with the remaining participants categorized as Non-HUA. SPSS, R, and "Zstats" software were used for data analysis. Results: Of the participants, 1,135 (24.7%) were in the HUA group, with 86.4% male. The ACAG, triglycerides (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) levels in the HUA group were significantly higher than those in the Non-HUA group, while HDL-C levels were significantly lower. ACAG was positively correlated with SUA, even after adjusting for age and gender. Non-linear analysis showed that when ACAG exceeded 12.64, each additional unit increase was associated with a 12% increase in the adjusted odds ratio for HUA. Mediation analysis revealed that TG and non-HDL-C partially mediated the association between ACAG and HUA, accounting for 28.3% and 13.5%, respectively. Conclusion: This is the first study to demonstrate a significant correlation between ACAG and HUA, with TG and non-HDL-C acting as mediators, providing new directions for prevention and intervention of HUA.
Keywords: Serumalbumin, Aniongap, Albumin-correctedaniongap, Hyperuricemia, Cardiovascular Diseases
Received: 17 Jul 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Yan, Shi, Zhang, Gong, Wei and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
ManLi Yan, Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China
Xiang Li, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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