REVIEW article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1671247
Research Progress on the Mechanism Underlying the Application of Mesenchymal Stem Cells in the Treatment of Male Infertility
Provisionally accepted
- 1TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China, Chengdu, China
- 2School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China, Chengdu, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Male infertility has become an increasingly prominent health issue worldwide. This review systematically evaluated the therapeutic application of different types of MSCs in various male infertility models. The therapeutic effects of MSCs are attributed to mechanisms such as in vivo and in vitro differentiation into germ cells, improved antioxidant capacity of testicular tissue, inhibited secretion of inflammatory factors and elevated anti-inflammatory level of testicular tissue, prevention of excessive apoptosis of testicular tissue cells, restoration of the normal secretion of sexual hormone levels in vivo, and regulation of sperm autophagy. Simultaneously, this study also emphasized on the latest progress in the research of MSC-Exos, with the discussion of its potential advantages over traditional MSC therapy. In addition, this review also elucidated challenges in the clinical translation of MSCs, including safety and standardization issues, as well as the necessity of conducting human clinical trials. On these basis, this research proposed corresponding improvement plans, such as developing engineered MSCs products, optimizing delivery methods and exploring combination therapies, which may provide potential reference for the clinical application of MSCs and MSC-Exos on a large scale.
Keywords: Mesenchymal Stem Cells, male infertility, testicles, sperm, Regenerative Medicine, Mesenchymal Stem Cells-Derived Exosomes
Received: 28 Jul 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Tian, Zhang, Tang, Guo, Gong, Yang, Dong and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Liang Dong, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China, Chengdu, China
Xujun Yu, TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.