ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Neuroendocrine Science
This article is part of the Research TopicNeuromodulation of mood and eating behaviorView all 7 articles
Differential response of the thyroid axis to high-fat diet-induced inflammatory and energy balance in juvenile and adult rats
Provisionally accepted
Elena Alvarez-Salas*
Paulina Soberanes-ChávezAlicia Andrade
Juan Luis Dolores-San JuanCinthia García-LunaGilberto Matamoros-Trejo
Patricia de Gortari*- National Institute of Psychiatry Ramon de la Fuente Muñiz (INPRFM), Mexico City, Mexico
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The hypothalamic–pituitary–thyroid (HPT) axis regulates metabolic rate and adapts to fluctuations in energy demand, through changing the expression of thyrotropin-releasing hormone (TRH) in the hypothalamic paraventricular nucleus (PVN), which drives those neuroendocrine responses. TRHergic neurons integrate multiple signals, including those arising from infections and dietary energy challenges. High-fat diet (HFD) intake, for example, activates PVN TRH mRNA and the HPT axis to manage energy excess; also, it promotes interleukin-1β (IL-1β)-mediated neuroinflammation disrupting axis function. How HPT axis adapts to simultaneous metabolic and inflammatory stimuli across development and under different durations of HFD exposure remains unelucidated. We investigated these interactions in juvenile (21 days old) and adult (2.5 months old) rats exposed to HFD for 4 or 12 weeks. Our findings showed that the longer the HFD exposure and the younger the animals, the greater the impairment of HPT axis function and body weight (b.w.) regulation. Short-term HFD feeding revealed age-dependent effects on b.w. since only juveniles were heavier than their controls, while the HPT axis was active on both. Neuroinflammatory responses also differed by developmental stage and duration. After 4 weeks of HFD, only juveniles displayed elevated IL-1β protein expression, whereas after 12 weeks, both age groups exhibited increased IL-1β; however, adults remained more resilient to cytokine overexpression than juveniles, regarding HPT axis function. Prolonged exposure promoted IL-1β–associated neuroinflammation, altered HPT axis regulation and favored leptin resistance, particularly in juveniles. These results highlighted the critical role of developmental stage and diet duration in HFD intake neuroendocrine effects.
Keywords: high-fat diet, Thyroid axis, interleukin-1β, Neuroinflammation, Hypothalamus
Received: 31 Jul 2025; Accepted: 04 Nov 2025.
Copyright: © 2025 Alvarez-Salas, Soberanes-Chávez, Andrade, Dolores-San Juan, García-Luna, Matamoros-Trejo and de Gortari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Elena Alvarez-Salas, alvareze@inprf.gob.mx
Patricia de Gortari, pdegortari@yahoo.com
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