ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Elevated Serum Chromogranin A Levels Are Independently Associated with Metabolic and Inflammatory Disturbances in Polycystic Ovary Syndrome
Provisionally accepted
Pınar Alarslan1*
Mehmet Doruk2- 1Istanbul Aydin Universitesi VM Medical Park Florya Hastanesi, Istanbul, Türkiye
- 2Izmir Bozyaka Egitim ve Arastirma Hastanesi, Izmir, Türkiye
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Introduction: Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology, frequently accompanied by insulin resistance, inflammation, and other metabolic disturbances. Chromogranin A (CgA), a glycoprotein secreted by neuroendocrine cells, has been linked to metabolic regulation and inflammatory processes, but its role in PCOS remains unexplored. This study aimed to evaluate serum CgA levels in women with PCOS and their association with metabolic, hormonal, and inflammatory parameters. Methods: This case-control study included 75 women with PCOS, diagnosed according to the Rotterdam criteria, and 75 age-matched healthy controls, recruited between January and April 2021 at Istanbul Aydın University Medical Park Florya Hospital. Serum CgA levels were measured using ELISA. Clinical parameters and biochemical markers, including glucose, insulin, HOMA-IR, lipid profile, sex hormones, SHBG, and hs-CRP, were assessed. Correlation, multivariate linear regression. Results: Mean serum CgA levels were significantly higher in the PCOS group than in controls (934.68 ± 256.27 vs. 642.27 ± 197.63 pg/mL, p < 0.001). PCOS patients also had higher glucose, insulin, HOMA-IR, triglycerides, hs-CRP, LH, total testosterone, FAI, and DHEA-S, with lower HDL-C and SHBG (all p < 0.05). CgA correlated positively with BMI, glucose, insulin, HOMA-IR, and hs-CRP, and remained independently associated with BMI, HOMA-IR, and hs-CRP in multivariate analysis. In multivariable models, CgA remained independently associated with BMI, HOMA-IR, and hs-CRP. These findings suggest that CgA reflects the metabolic–inflammatory milieu accompanying PCOS rather than indicating PCOS per se. This is a provisional file, not the final typeset article Discussion: Elevated CgA levels in PCOS are independently associated with obesity, insulin resistance, and low-grade inflammation. CgA may serve as a novel biomarker for metabolic risk stratification in PCOS, warranting validation in larger, prospective studies.
Keywords: PCOS1, chromogranin A2, insulin resistance3, inflammation4, metabolic dysfunction5
Received: 09 Aug 2025; Accepted: 27 Nov 2025.
Copyright: © 2025 Alarslan and Doruk. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Pınar Alarslan
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