Lower body mass index potentiates the association between late-night dinner and the prevalence of proteinuria

Jun Muratsu^1*Hiroshi Akasaka²Kei Kamide³Makiko Morita¹Masato Hayashi¹Ayaka Nariyama¹Kota Okamoto¹Tatsuya Wada¹Katsuhiko Sakaguchi⁴Yan Zhang¹Daisaku Masuda¹Takashi Shigematsu¹Koichi Yamamoto³Hiromi Rakugi⁵

• ¹Rinku Sogo Iryo Center, Izumisano, Japan
• ²Iwate Ika Daigaku Igakubu Daigakuin Igaku Kenkyuka, Shiwa District, Japan
• ³Osaka Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Suita, Japan
• ⁴Ippan Zaidan Hojin Sumitomo Byoin, Osaka, Japan
• ⁵Osaka Rosai Byoin, Sakai, Japan

Background: The presence of proteinuria or microalbuminuria is significantly associated with an increased risk of cardiovascular disease and all-cause mortality. Several studies reported the association between unhealthy eating patterns and proteinuria. While unhealthy eating patterns are a risk factor for obesity, they have also been reported to be a health risk in non-obese people without kidney disease. This cross-sectional study aimed to assess the association between late-night dinner and the prevalence of proteinuria in non-obese subjects with normal renal function. Methods: The present study included 2,127 participants (1,028 males and 1,099 females) with an estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2 and no history of kidney disease who underwent a health checkup at Rinku General Medical Center. To evaluate the impact of late-night dinner on prevalence of proteinuria (defined as dipstick proteinuria of ≥ ±), we applied logistic regression models adjusted for clinically relevant factors. Results: Late-night dinner was reported in 297 males (28.9%) and 176 females (16.0%). Multivariable adjusted logistic regression models showed that late-night dinner was significantly associated with the prevalence of proteinuria in males. This association remained significant in lower body mass index (BMI) males (BMI< 24.9 kg/m2), even after adjusting for clinically relevant factors (adjusted odds ratios were 3.57 [1.34-9.48] and 3.15 [1.22-8.13], respectively). In contrast, this association was not evident in participants with a higher BMI ≥ 24.9 kg/m2. Conclusion: The effect of late-night dinner on proteinuria may vary depending on BMI, particularly in males.