REVIEW article
Front. Endocrinol.
Sec. Thyroid Endocrinology
The Mechanism and Application of Scrophulariae Radix in the Treatment of Endocrine Disorders: Focusing on Thyroid Diseases and Diabetes Mellitus
Provisionally accepted
- Shandong University of Traditional Chinese Medicine, Jinan, China
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Abstract: Endocrine disorders are prevalent worldwide, with particularly high incidence rates of thyroid diseases and diabetes mellitus (DM), which impose a substantial burden on healthcare systems. Life-long medication is often required to manage these conditions. Scrophulariae Radix is a traditional Chinese medicine. It contains various chemical components, such as iridoids, phenylpropanoids, and organic acids. These components show anti-inflammatory, antioxidative, and immunomodulatory effects. They have potential to treat endocrine disorders. They are especially effective for thyroid diseases and DM. This review aims to summarize the mechanisms and effects through which Scrophulariae Radix affects thyroid diseases and DM, providing further guidance for clinical treatment.
Keywords: Scrophulariae Radix, Endocrine disorders, Thyroid Diseases, Diabetes Mellitus, Pharmacological effects, mechanisms
Received: 13 Aug 2025; Accepted: 05 Nov 2025.
Copyright: © 2025 Song, Li, Shi, Liu, Qu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Furong Wang, 15168888786@163.com
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