ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
The Relationship Between Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Cardiovascular High-Risk: A Cross-Sectional Investigation
Provisionally accepted
Pengcheng Li1,2Jirui Cai2Shuaifang Yuan2Yapeng Li1
Huiting Shi1Cui Liang1
He Bing2Qiaotao Xie2Baocang Lei2
Jing Bai2
Nan Wang2
Dongliang Liu2Qichao Wang3
Jian-Wei Xiong2Jin Wang2
Haoran Wang2*- 1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- 2Luohe Central Hospital, Luohe, China
- 3Luohe Medical College, Luohe, China
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Abstract Aims The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio reflects the balance between atherogenic and anti-atherogenic lipid fractions. The study aims to investigate the utility of the TG/HDL-C ratio in identifying high-risk groups for cardiovascular disease (CVD) within the general population. Methods The current study was a branch of the ChinaHEART cohort in middle China that involved a total of 6,593 community-dwelling adults. We examine the association between TG/HDL-C and CVD high-risk in a cross-sectional investigation. Results Results from restricted cubic spline and ROC analyses revealed a significant relationship between higher TG/HDL-C levels and increased odds of CVD high-risk, with the ratio exhibiting good discriminatory power (AUC=0.820 in the fully adjusted model). Logistic regression further supported this association, indicating a 1.21-fold rise in the odds of high-risk for each unit increase in TG/HDL-C. Conclusions The TG/HDL ratio shows promise for CVD risk assessment. Incorporating the TG/HDL ratio into risk assessment models may provide supplementary information to healthcare professionals for risk stratification.
Keywords: TG/HDL-C ratio, cardiovascular high-risk, Cross-sectional study, Public Health, lipid fractions
Received: 21 Aug 2025; Accepted: 05 Nov 2025.
Copyright: © 2025 Li, Cai, Yuan, Li, Shi, Liang, Bing, Xie, Lei, Bai, Wang, Liu, Wang, Xiong, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Haoran Wang, washingtonhr@163.com
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