ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Gut Endocrinology
Relationship between Helicobacter Pylori infection and metabolic syndrome components in adults
Provisionally accepted
Yan-fei Jiang1,2
Long Zhong3,4,5Jing-jing Guo6Qiao-fen Wang7Jia-xu Gu8Jiayu Huang6,9Yan-jing Liu6Yuan Lin6
Donghui Lu6*Xiao-fen Lian6*- 1Shenzhen Luohu Hospital Group Luohu People's Hospital, Shenzhen, China
- 2Shenzhen Third People's Hospital, Shenzhen, China
- 3Shenzhen University Medical School, Shenzhen, China
- 4Peking University Shenzhen Hospital Department of Urology, Shenzhen, China
- 5Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China
- 6Peking University Shenzhen Hospital Department of Endocrinology, Shenzhen, China
- 7Hainan General Hospital, Haikou, China
- 8Peking University Shenzhen Hospital Department of Dermatology, Shenzhen, China
- 9Shantou University Medical College, Shantou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background and Aim: Helicobacter pylori (H. pylori, HP) infection plays a significant role in the development and progression of various intra-gastric and extra-gastric diseases. Its infection is associated with numerous factors, including a series of metabolic-related diseases, and the potential connections between them remain highly controversial. Meanwhile, the prevalence of metabolic diseases has been increasing exponentially with changes in economic levels and lifestyles. Exploring the correlations and potential mechanisms between HP and metabolic diseases is crucial for future disease prevention and control. Due to the ongoing controversy surrounding its relevance and the absence of articles investigating the metabolic-related mediating mechanisms and threshold effects of related metabolic diseases leading to HP infection, this study holds significant importance for guiding future lifestyle and disease control. Methods: By collecting relevant test and examination indicators from 7,387 participants at Peking University Shenzhen Hospital, we analyzed the potential pathogenic mechanisms using statistical methods such as regression analysis, mediation analysis, and threshold analysis. Results: We found that factors such as blood glucose levels (fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c)), Body Mass Index (BMI), and blood pressure (Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP)) were the main risk factors influencing the target outcomes in this study, while higher levels of Albumin (Alb) may have a certain protective effect, with BMI playing a particularly significant role among these factors. Conclusion: This discovery has deepened our understanding of metabolic diseases, BMI, related metabolic indicators, and HP infection.
Keywords: Metabolic syndrome component, Helicobacter pylori, Inflammatory factors, HbA1c, diabetes, Obesity
Received: 02 Sep 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Jiang, Zhong, Guo, Wang, Gu, Huang, Liu, Lin, Lu and Lian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Donghui Lu, ludongh@sina.com
Xiao-fen Lian, lxf198804@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.