REVIEW article
Front. Endocrinol.
Sec. Bone Research
This article is part of the Research TopicRecent Advances in the Management of Osteoporosis: Prevention, Diagnosis and TreatmentView all 14 articles
Application of Circadian Rhythm in Osteoporosis Prevention and Treatment: From Light, Diet, and Exercise to Chronotherapy
Provisionally accepted
- 1People's Hospital of Quzhou, Quzhou, China
- 2Wuxi Ninth People's Hospital, Wuxi, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Osteoporosis is a prevalent systemic bone disorder characterized by reduced bone mass, deterioration of bone microstructure, and increased bone fragility, significantly compromising the quality of life, particularly among elderly and postmenopausal populations. The circadian clock serves as a critical physiological mechanism for maintaining homeostasis and regulating rhythmic biological processes, playing an essential role in bone metabolism regulation. Recent studies have revealed strong associations between circadian disruption and the development and progression of osteoporosis, providing novel perspectives for intervention strategies. This comprehensive review examines the role of the circadian clock in osteoporosis and explores the current applications and future prospects of circadian-based interventions, including light exposure, dietary modifications, physical activity, and chronotherapy, in osteoporosis management. The objective is to offer comprehensive and precise strategic insights for osteoporosis prevention and treatment.
Keywords: Circadian clock, Osteoporosis, Chronotherapy, time-restricted feeding, Exercise
Received: 03 Sep 2025; Accepted: 19 Nov 2025.
Copyright: © 2025 Qian, Huang and Zhai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiaocheng Zhai, zhaiqiaocheng@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.