ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cancer Endocrinology
This article is part of the Research TopicExploring Endocrine and Nutritional Metabolism's Role in Tumor Development and ProgressionView all 4 articles
Association Between Triglyceride–Glucose Index (TyG) and Its Derivatives and Lung Adenocarcinoma Risk: A Case–Control Study in Chinese Adults
Provisionally accepted
- 1First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China
- 2Jinzhou Medical University, Jinzhou, China
- 3China Medical University, Shenyang, China
- 4Yingkou Central Hospital, Yingkou, China
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Background and objectives: Lung cancer is the leading cause of cancer-related death worldwide, and China accounts for nearly one-third of global cases and deaths. Insulin resistance (IR) has been implicated in cancer development, but evidence for its association with lung adenocarcinoma remains inconsistent, especially in Asian populations. The triglyceride–glucose (TyG) index and its derivatives are simple surrogate markers of IR. This study aimed to examine the associations between the TyG index, its derivatives (TyG-BMI, TyG-WC, TyG/HDL-C), and lung adenocarcinoma risk in Chinese adults. Methods: We conducted a case–control study including 200 histologically confirmed lung adenocarcinoma patients and 500 age-and sex-matched healthy controls from the First Affiliated Hospital of Jinzhou Medical University (September 2023–September 2024). Anthropometric and biochemical measurements were obtained using standardised protocols. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age, BMI, and smoking status. Restricted cubic spline (RCS) analysis assessed dose–response patterns, and receiver operating characteristic (ROC) curves evaluated predictive performance. Results: Lung cancer patients had significantly higher TyG index and derivative values, as well as higher systolic blood pressure, HbA1c, LDL-C, and TC levels compared with controls (all P < 0.05). RCS analysis showed generally linear positive associations between all TyG-related indices and lung cancer risk, with the steepest increase for TyG/HDL-C. ROC analysis indicated that the TyG/HDL-C ratio achieved the highest predictive performance among the evaluated markers, with an AUC of 0.851. Conclusion: The TyG index and its derivatives are positively associated with Lung adenocarcinoma risk in Chinese adults, with the TyG index demonstrating the greatest predictive performance. These easily obtainable metabolic markers may serve as low-cost tools for identifying individuals at elevated risk of Lung adenocarcinoma. Prospective studies are warranted to confirm these findings and explore underlying biological mechanisms.
Keywords: Triglyceride-glucose index, Insulin Resistance, Lung Adenocarcinoma, Metabolic biomarker, case-control study
Received: 03 Sep 2025; Accepted: 19 Nov 2025.
Copyright: © 2025 Qiu, Xie, He, Cong, Huang and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bo Huang, huangb@jzmu.edu.cn
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