MINI REVIEW article
Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1702104
This article is part of the Research TopicRecent Advances in the Management of Osteoporosis: Prevention, Diagnosis and TreatmentView all 6 articles
The role of bone-derived factors in bone and muscle communication
Provisionally accepted
- Inner Mongolia Agricultural University, Hohhot, China
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The interaction between bone and muscle was traditionally considered to be mechanical. However, recent insights into the endocrine functions of these two tissues have led to an emerging concept that bone-muscle biochemical crosstalk occurs through soluble factors. In light of the identification of novel bone-derived factors in recent years, more focus has been shifted to the role of bone in this partnership. Primary factors identified include osteocalcin (Ocn), fibroblast growth factor 23 (FGF23), insulin-like growth factor 1 (IGF1), sclerostin (Sost), prostaglandin E2 (PGE2), fibroblast growth factor 9 (FGF9), Wnt3a, and transforming growth factor beta (TGF-β). This review aims to summarize the current knowledge regarding the influence of bone-derived factors on muscle function. A comprehensive understanding of the cellular and molecular mechanisms underlying bone-muscle communication may facilitate the identification of potential therapeutic strategies for the twin diseases of osteoporosis and sarcopenia.
Keywords: Bone, Muscle, Endocrine organ, bone-derived factors, Osteoporosis, Sarcopenia
Received: 09 Sep 2025; Accepted: 29 Sep 2025.
Copyright: © 2025 Li, Qi and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guobin Li, guobinl@126.com
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