REVIEW article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1706091
ANGPTL3 and Residual Atherosclerotic Risk: From Lipid Metabolism to Therapeutic Targeting
Provisionally accepted
- The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
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Despite achieving recommended low-density lipoprotein cholesterol (LDL-C) targets, many patients remain at high risk of cardiovascular events due to elevated triglyceride-rich lipoproteins and remnants. Angiopoietin-like protein 3 (ANGPTL3) has emerged as a promising therapeutic target for addressing this residual risk. As a liver-secreted regulator of lipoprotein metabolism, ANGPTL3 influences triglycerides, LDL-C, and high-density lipoprotein cholesterol through inhibition of lipoprotein lipase and endothelial lipase. Human genetic studies and pharmacologic interventions consistently show that ANGPTL3 inhibition improves lipid profiles and lowers apolipoprotein B–containing lipoproteins, independent of LDL receptor function. This review integrates biological, genetic, and clinical evidence, and provides an overview of novel ANGPTL3-targeted therapies, offering new perspectives for cardiovascular prevention and lipid management.
Keywords: Angiopoietin-like protein 3, Lipid Metabolism, triglyceride, Cholesterol, Atherosclerosis
Received: 18 Sep 2025; Accepted: 16 Oct 2025.
Copyright: © 2025 Weng, Ding, Lin and Chai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jinxiu Lin, linjinxiu@fjmu.edu.cn
Dajun Chai, dajunchai-fy@fjmu.edu.cn
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