ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Selected Parameters Of Epidermal Barrier In Juveniles With Type 1 Diabetes Correspond With The Severity Of Diabetes – An Observational Study
Provisionally accepted
Klaudia Bogusz-Górna*
Adriana Polanska
Aleksandra Dańczak-Pazdrowska
Ryszard Żaba
PIOTR FICHNAAndrzej Kędzia- Uniwersytet Medyczny im Karola Marcinkowskiego w Poznaniu, Poznań, Poland
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Our study aimed to evaluate the epidermal barrier function in children with type 1 diabetes. To the author's knowledge, no studies have been conducted on epidermal barrier parameters, including TEWL and measurement of epidermal hydration, in children and adolescents with type 1 diabetes. Methods: One hundred sixty children and adolescents aged 6-18, 125 patients with type 1 diabetes, and 35 healthy volunteers participated in the study: a detailed clinical evaluation, transepidermal water loss (TEWL) measurement, and epidermal hydration (corneometry) were carried out. Results: Poor metabolic control in type 1 diabetes, higher HbA1c(%), and more frequent hyperglycemia impact TEWL and epidermis hydration. Also, the level of BF(%) correlated positively with TEWL. Conclusions: Extended supplementary tests – the assessment of TEWL and corneometry – could be included in the periodic examinations of children and adolescents with type 1 diabetes mellitus. Clinicians should always pay attention to dry skin in children with diabetes, and noninvasive examination (TEWL measurement and corneometry) may allow us to isolate a group at risk of neuropathy or the development of the diabetic foot. Further tests enabling detailed assessment of the usefulness of TEWL measurements and corneometry are needed
Keywords: Children, adolescents, type 1 diabetes, Epidermal barrier, Transepidermal water loss, TEWL, epidermis hydration, Corneometry
Received: 20 Sep 2025; Accepted: 03 Nov 2025.
Copyright: © 2025 Bogusz-Górna, Polanska, Dańczak-Pazdrowska, Żaba, FICHNA and Kędzia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Klaudia Bogusz-Górna, kl.bogusz@gmail.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.