ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Thyroid Endocrinology
Application of the Novel Tracer Mitoxantrone 1 Hydrochloride in Lymph Node Visualization During 2 Lateral Neck Dissection for Thyroid Carcinoma 3 4
Provisionally accepted
Wu Li
Hui Li
Yulong TangPeng Wu
Shiwei ZhouXiaohua SongZeyang Liu
Zhiyuan Wang
Feng Shixibin XiaZhaodong Ai*
Xiaowei Peng*- Hunan Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha, China
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Background: In this study, a novel lymph node tracer—mitoxantrone hydrochloride 18 injection for tracing (MHI)—was intraoperatively administered into suspected metastatic lateral 19 cervical lymph nodes of patients with papillary thyroid carcinoma (PTC), aiming to evaluate its 20 staining efficacy and clinical value in enhancing the completeness of lateral neck dissection 21 (LND). 22 Methods: A prospective controlled study was conducted at Hunan Cancer Hospital between 23 December 2023 and May 2024, enrolling a total of 67 patients diagnosed with thyroid carcinoma. 24 After informed consent, patients were allocated to either MHI or methylene blue group. Subjects 25 were divided into an MHI group (n = 42) and a methylene blue group (n = 25). All patients 26 underwent LND. 27 Results: The results demonstrated no statistically significant differences between the two 28 groups in terms of operative time, total number of lymph nodes dissected, cervical drainage 29 volume, or postoperative length of hospital stay (P > 0.05). However, the MHI group exhibited 30 superior staining of suspected metastatic lymph nodes, with a greater number of metastatic lymph 31 nodes and a higher positive ratio compared to the methylene blue group (P < 0.05). 32 Conclusion: MHI causes minimal tissue contamination and can effectively enhance the 33 thoroughness of LND in patients with thyroid carcinoma, demonstrating high clinical application 34 value.
Keywords: Papillary thyroid carcinoma, Neck Dissection, Mitoxantrone hydrochloride, Lymph node tracer, Staining Efficacy
Received: 25 Sep 2025; Accepted: 28 Nov 2025.
Copyright: © 2025 Li, Li, Tang, Wu, Zhou, Song, Liu, Wang, Shi, Xia, Ai and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhaodong Ai
Xiaowei Peng
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