Plasma corin levels provide minimal prognostic utility in left atrial reverse remodeling after catheter ablation of atrial fibrillation: An observational study

FeiFei Chen^1*Qianqian Wang¹Yang Li¹Xiaoyang Yuan¹Yue Gong²Keyi Song¹Chunkai Li¹Jinqiu Liu¹Yichang Zhao^1*

• ¹First Affiliated Hospital, Dalian Medical University, Dalian, China
• ²Central Hospital of Dalian University of Technology, Dalian, China

Objective: To assess the impact of plasma corin levels on left atrial reverse remodeling (LARR) in patients with atrial fibrillation (AF) after catheter ablation (CA). Methods: This prospective, single-center, observational study included 335 patients undergoing first CA of AF. All patients underwent at least two echocardiographic examinations at intervals of ≥three months. Corin was measured before and one day after CA. LARR was defined as a reduction of ≥ 20% in left atrial volume index. Results: After a median of 29.53 months of follow-up, 94 patients exhibited LARR. The plasma corin concentrations drawn pre-and post-procedure in the LARR group were 442.85 [241.25, 631.68] and 516.83 [362.4,697.84] pg/mL, and those were significantly higher than those in the non-LARR group (393.82 [207.09, 558.11] and 473.77 [320.88, 665.75] pg/mL; P = 0.036 and P = 0.047). Kaplan-Meier survival curve showed high baseline corin concentrations indicated a higher rate of LARR than low corin concentrations (P = 0.014). Cox regression found plasma corin levels before or after the procedure were not associated with LARR in AF patients after CA, with or without adjusting for confounding factors. Absence of hypertension (P = 0.001, OR = 0.33) and diabetes mellitus (P = 0.007, OR = 0.269) was associated with a greater likelihood of LARR in AF patients after CA. Conclusions: Although plasma corin concentrations were increased in LARR group, it provided minimal prognostic utility in LARR after CA of AF.