MINI REVIEW article
Front. Endocrinol.
Sec. Reproduction
This article is part of the Research TopicMale Infertility and Erectile Dysfunction: Shared Pathways, Diagnostics, and Therapeutic InnovationsView all 3 articles
Management of Male Premature Ejaculation: From Past to Future
Provisionally accepted
Jiaqing CHANG1
Weiwei ZHAO1Lili MA2Juan ZHAO1Qiming LI1Xueyang WANG1Haichao JU1Xinping WANG3Xiping XING3*- 1Gansu University of Chinese Medicine, Lanzhou, China
- 2Lanzhou First People's Hospital, 兰州市, China
- 3Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China
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Premature ejaculation (PE) is a common disease of the male reproductive system, which seriously affects the quality of life of patients and their partners. Currently, PE is regarded as a biopsychosocial disease with complex etiologies and diverse treatment methods.Oral selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PE, with advantages such as high safety, rapid onset of action, and non-invasiveness. However, topical anesthetics, behavioral and psychological therapies, device-assisted treatments, and traditional Chinese medicine (TCM) can also serve as alternative therapies for patients intolerant to SSRIs.With the rapid development of technology, some new methods—such as low-intensity extracorporeal shock wave therapy (Li-ESWT) and transcutaneous electrical nerve stimulation (TENS)—can even improve PE through mechanisms like regulating nerve conduction and improving local microcirculation. These are all important directions for the future treatment of male PE.In this mini-review, we will elaborate on these therapeutic approaches.
Keywords: SSRIs, Topical local anesthetics, Psychological and behavioral therapies, Device-assisted therapy, Low-Intensity Shockwave Therapy, Percutaneous tibial nerve stimulation, surgical treatment
Received: 03 Oct 2025; Accepted: 17 Nov 2025.
Copyright: © 2025 CHANG, ZHAO, MA, ZHAO, LI, WANG, JU, WANG and XING. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiping XING, xxp214@126.com
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