ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Renal Endocrinology
This article is part of the Research TopicCardiovascular Risks in Cardiovascular-Kidney-Metabolic Syndrome: Mechanisms and TherapiesView all 12 articles
Cross-Sectional and Longitudinal Associations Between Pan-Immune-Inflammation Value and Serum Uric Acid
Provisionally accepted
- 1Shanghai Institute of Hypertension, Shanghai Jiao Tong University, Shanghai, China
- 2Jiading district Waigang Hospital,, Shanghai, China
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Background Elevated serum uric acid (SUA) correlates with inflammation, but the pan-immune inflammation value (PIV)—a novel integrated inflammatory marker—has not been explored in relation to SUA. We investigated cross-sectional and longitudinal PIV-SUA associations. Methods We analyzed 5,766 participants aged ≥60 years from a 2018 cardiovascular examination cohort with 2022 follow-up. The PIV was calculated as neutrophil number × platelet number × monocyte number/lymphocyte number, with cell counts expressed as ×1000 cells/μL. Hyperuricemia was defined as SUA concentrations ≥ 420 μmol/L (7 mg/dL) in males and ≥ 360 μmol/L (6 mg/dL) in females. Cross-sectional associations were assessed via multivariate linear/logistic regression; longitudinal associations via Cox regression. Results At baseline, hyperuricemia prevalence was 22.4% among 5,766 participants (mean age 68.5 years). Restricted cubic spline showed a nonlinear PIV-SUA relationship. In fully adjusted models, each 1-SD PIV increase associated with higher SUA (β±SE: 3.7±1.1; P<0.0001). PIV quartiles (vs. lowest) showed β values: Q2=7.5, Q3=6.7, Q4=12.5 (P trend<0.001). Logistical regression revealed each 1-SD PIV increase linked to higher hyperuricemia risk (OR=1.12, 95%CI 1.05-1.29; P=0.0003). PIV quartiles (vs. lowest) had ORs: Q2=1.27, Q3=1.23, Q4=1.54 (P trend<0.001). Over 4-year follow-up, Cox regression indicated a J-curve relationship between PIV and SUA/hyperuricemia, with the lowest risk at PIV quartile 2. Conclusions PIV showed a nonlinear relationship with serum uric acid and hyperuricemia in cross-sectional analyses, while exhibiting a J-curve relationship in longitudinal studies. These suggest dynamic interactions between inflammatory markers and uric acid metabolism, dependent on inflammation duration.
Keywords: Serum uric acid, Hyperuricemia, pan-immune inflammation value, Inflammation, Elderly
Received: 08 Oct 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Sheng, Lu, Chu, Wang, Cheng, Gong and Huo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chang-Sheng Sheng
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