Frontiers in Genetics | Applied Genetic Epidemiology

Original Research

Published on 23 May 2025

The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells

in Applied Genetic Epidemiology

Jianguo Zhang
Yanhui Liu
Hailong Zhang
Lin Yang
Danjing Sun
Lili Xiao
Xiaoyun Wang
Xiangming Wu

Frontiers in Genetics

doi 10.3389/fgene.2025.1536672

2,000 views

Original Research

Published on 23 May 2025

Global, regional, and national burden of glucose-6-phosphate dehydrogenase (G6PD) deficiency from 1990 to 2021: a systematic analysis of the global burden of disease study 2021

in Applied Genetic Epidemiology

Zhengyu Yu
Qiang Xiong
Zhongwang Wang
Linfeng Li
Ting Niu

Frontiers in Genetics

doi 10.3389/fgene.2025.1593728

7,527 views
9 citations

Original Research

Published on 15 May 2025

Integrated transcriptomic analysis of COVID-19 stages and recovery: insights into key gene signatures, immune features, and diagnostic biomarkers through machine learning

in Applied Genetic Epidemiology

Zhiyuan Gong
He An

Frontiers in Genetics

doi 10.3389/fgene.2025.1599867

2,728 views
2 citations

Original Research

Published on 14 May 2025

EGFR polymorphisms drive lung cancer risk and survival disparities: a genotype-expression-outcome cohort study

in Applied Genetic Epidemiology

Chao Zuo
Ziqiang Wang
Yi Liu
Jing Cheng
Dongli Yang
Yu Wang
Yongchao Qiao

Frontiers in Genetics

doi 10.3389/fgene.2025.1591539

2,253 views

Original Research

Published on 09 May 2025

Nonmetastatic cell 1 gene polymorphisms are associated with the clinical progression and prognoses of patients with colorectal cancer

in Applied Genetic Epidemiology

Yabin Liu
Tianliang Bai
Zhenxi Zhang
Yanjun Xu
Dexian Kong

Frontiers in Genetics

doi 10.3389/fgene.2025.1485855

1,308 views

Original Research

Published on 01 May 2025

Development and validation of a polygenic risk score for height in a Greek cohort: Association with blood pressure measurements

in Applied Genetic Epidemiology

Ioanna Panagiota Kalafati
Margaritis Tsifintaris
Maria Dimitriou
Effimia Grigoriou
Panagiotis Moulos
George V. Dedoussis

Frontiers in Genetics

doi 10.3389/fgene.2025.1538975

3,013 views

Original Research

Published on 15 Apr 2025

Multi-trait GWAS identifies pleiotropic loci associated with colorectal cancer in East Asian populations

in Applied Genetic Epidemiology

Xiqi Chen
Yong Zhu
Peng Zhong
Guangdong Xie

Frontiers in Genetics

doi 10.3389/fgene.2025.1590652

2,762 views
1 citation

Data Report

Published on 26 Mar 2025

Adaptation of key bacterial vaginosis-associated bacteria to a medium simulating genital tract secretions: a transcriptomic analysis

in Applied Genetic Epidemiology

Lúcia G. V. Sousa
Angela França
Vânia Pinheiro
Christina A. Muzny
Nuno Cerca

Frontiers in Genetics

doi 10.3389/fgene.2025.1552307

3,177 views

Original Research

Published on 25 Mar 2025

Genetic analysis reveals the shared genetic architecture between breast cancer and atrial fibrillation

in Applied Genetic Epidemiology

Yang Yang
Jiayi Chen
XiaoHua Zhao
Fuhong Gong
Ruimin Liu
Jingge Miao
Mengping Lin
Fei Ge
Wenlin Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1450259

5,467 views

Review

Published on 11 Mar 2025

Bibliometric analysis of case-control studies on the association between HLA alleles and multiple sclerosis in adults

in Applied Genetic Epidemiology

Enola Maer
Marjorie Maya Hubacher
Livia Livint Popa
Dana Marieta Fodor
Razvan Mircea Chereches
Dafin F. Muresanu
Vitalie Vacaras
Maria Chiriac
Horea Vladi Matei
Nicu Catalin Draghici

Frontiers in Genetics

doi 10.3389/fgene.2025.1524360

2,205 views

Brief Research Report

Published on 11 Mar 2025

Retrospective chart review of inherited and idiopathic dystonia

in Applied Genetic Epidemiology

A. Alakkas
H. Shinawi
J. A. Bajwa
O. Alsinaidi
A. Al-Hashim

Frontiers in Genetics

doi 10.3389/fgene.2025.1504744

2,010 views

Review

Published on 05 Mar 2025

Sex differences in asthma: omics evidence and future directions

in Applied Genetic Epidemiology

Bichen Peng
Weiyi Ye
Shuai Liu
Yue Jiang
Ziang Meng
Miao Guo
Lili Zhi
Xiao Chang
Lei Shao

Frontiers in Genetics

doi 10.3389/fgene.2025.1560276

4,306 views
6 citations

Original Research

Published on 05 Mar 2025

Identification of four key genes related to the diagnosis of chronic obstructive pulmonary disease using bioinformatics analysis

in Applied Genetic Epidemiology

Jinxia Li
Xiuming Liu
Yonghu Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1499996

2,985 views
2 citations

Editorial

Published on 19 Feb 2025

Editorial: Advancements and prospects of genome-wide association studies

in Applied Genetic Epidemiology

Ayo P. Doumatey
Yafang Li
Juan Carlos Fernandez-Lopez

Frontiers in Genetics

doi 10.3389/fgene.2025.1564006

3,325 views

Original Research

Published on 17 Feb 2025

Exploring genetic loci linked to COVID-19 severity and immune response through multi-trait GWAS analyses

in Applied Genetic Epidemiology

Ziang Meng
Chumeng Zhang
Shuai Liu
Wen Li
Yue Wang
Qingyi Zhang
Bichen Peng
Weiyi Ye
Yue Jiang
Yingchao Song

Frontiers in Genetics

doi 10.3389/fgene.2025.1502839

3,163 views
2 citations

Original Research

Published on 08 Jan 2025

Genetic insights and therapeutic avenues: unraveling the role of polyunsaturated fatty acids as mediators between hypothyroidism and Von Willebrand disease through Mendelian randomization

in Applied Genetic Epidemiology

Wenting Zhou
Rui He
Ruwei Ou

Frontiers in Genetics

doi 10.3389/fgene.2024.1426401

2,156 views

Original Research

Published on 03 Jan 2025

Association between METTL14 gene polymorphisms and risk of ovarian endometriosis

in Applied Genetic Epidemiology

Zijun Zhou
Youkun Jie
Xianyue Hu
Guange Chen
Yanjing Bao
Zhenbo OuYang
Liangzhi Wu
Tianyang Gao
Qiushi Zhang
Wenfeng Hua

Frontiers in Genetics

doi 10.3389/fgene.2024.1460216

2,607 views

Original Research

Published on 02 Dec 2024

Genetic surveillance shows spread of ACT resistance during period of malaria decline in Vietnam (2018-2020)

in Applied Genetic Epidemiology

Johanna Helena Kattenberg
Mathijs Mutsaers
Van Hong Nguyen
Thi Hong Ngoc Nguyen
Arlette Umugwaneza
Maria Lara-Escandell
Xuan Xa Nguyen
Thi Huong Binh Nguyen
Anna Rosanas-Urgell

Frontiers in Genetics

doi 10.3389/fgene.2024.1478706

5,441 views
3 citations

Editorial

Published on 26 Nov 2024

Editorial: Women in applied genetic epidemiology

in Applied Genetic Epidemiology

Qi Guo
Kristina Allen-Brady
Marta Olszewska

Frontiers in Genetics

doi 10.3389/fgene.2024.1508169

2,014 views

Original Research

Published on 25 Nov 2024

Causal relationship between diabetes mellitus and lung cancer: a two-sample Mendelian randomization and mediation analysis

in Applied Genetic Epidemiology

Xiaolin Yu
Binfan Fu
Taizhen Sun
Xu Sun

Frontiers in Genetics

doi 10.3389/fgene.2024.1449881

3,694 views
3 citations

Original Research

Published on 19 Nov 2024

Causal effect of waist-to-hip ratio on non-alcoholic fatty liver disease: a mendelian randomization study

in Applied Genetic Epidemiology

Shihao Wu
Yuhong He
Jiaxing Li
Sijie Wang

Frontiers in Genetics

doi 10.3389/fgene.2024.1414835

1,922 views
2 citations

Original Research

Published on 06 Nov 2024

De novo SCN1A missense variant in a patient with Parkinson’s disease

in Applied Genetic Epidemiology

Majed Alluqmani
Abdulfatah M. Alayoubi
Jamil A. Hashmi
Sulman Basit

Frontiers in Genetics

doi 10.3389/fgene.2024.1496683

2,352 views

Original Research

Published on 06 Nov 2024

Implementation of a national rapid prenatal exome sequencing service in England: evaluation of service outcomes and factors associated with regional variation

in Applied Genetic Epidemiology

Rema Ramakrishnan
Corinne Mallinson
Steven Hardy
Jennifer Broughan
Maisie Blyth
Gabriella Melis
Catherine Franklin
Melissa Hill
Rhiannon Mellis
Wing Han Wu

Frontiers in Genetics

doi 10.3389/fgene.2024.1485306

2,785 views
5 citations

Original Research

Published on 15 Oct 2024

ONT sequencing identifies a high prevalence of crt sensitive, triple mutant dhfr and single mutant dhps parasites within an ANC population in Nigeria

in Applied Genetic Epidemiology

Adebanjo Jonathan Adegbola
Leonard Ndwiga
Kevin Wamae
Victor Osoti
Oluseye Oladotun Bolaji
Philip Bejon
Lynette Isabella Ochola-Oyier

Frontiers in Genetics

doi 10.3389/fgene.2024.1470156

3,033 views
3 citations

450 articles

articles

The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells

Global, regional, and national burden of glucose-6-phosphate dehydrogenase (G6PD) deficiency from 1990 to 2021: a systematic analysis of the global burden of disease study 2021

Integrated transcriptomic analysis of COVID-19 stages and recovery: insights into key gene signatures, immune features, and diagnostic biomarkers through machine learning

EGFR polymorphisms drive lung cancer risk and survival disparities: a genotype-expression-outcome cohort study

Nonmetastatic cell 1 gene polymorphisms are associated with the clinical progression and prognoses of patients with colorectal cancer

Development and validation of a polygenic risk score for height in a Greek cohort: Association with blood pressure measurements

Multi-trait GWAS identifies pleiotropic loci associated with colorectal cancer in East Asian populations

Adaptation of key bacterial vaginosis-associated bacteria to a medium simulating genital tract secretions: a transcriptomic analysis

Genetic analysis reveals the shared genetic architecture between breast cancer and atrial fibrillation

Bibliometric analysis of case-control studies on the association between HLA alleles and multiple sclerosis in adults

Retrospective chart review of inherited and idiopathic dystonia

Sex differences in asthma: omics evidence and future directions

Identification of four key genes related to the diagnosis of chronic obstructive pulmonary disease using bioinformatics analysis

Editorial: Advancements and prospects of genome-wide association studies

Exploring genetic loci linked to COVID-19 severity and immune response through multi-trait GWAS analyses

Genetic insights and therapeutic avenues: unraveling the role of polyunsaturated fatty acids as mediators between hypothyroidism and Von Willebrand disease through Mendelian randomization

Association between METTL14 gene polymorphisms and risk of ovarian endometriosis

Genetic surveillance shows spread of ACT resistance during period of malaria decline in Vietnam (2018-2020)

Editorial: Women in applied genetic epidemiology

Causal relationship between diabetes mellitus and lung cancer: a two-sample Mendelian randomization and mediation analysis

Causal effect of waist-to-hip ratio on non-alcoholic fatty liver disease: a mendelian randomization study

De novo SCN1A missense variant in a patient with Parkinson’s disease

Implementation of a national rapid prenatal exome sequencing service in England: evaluation of service outcomes and factors associated with regional variation

ONT sequencing identifies a high prevalence of crt sensitive, triple mutant dhfr and single mutant dhps parasites within an ANC population in Nigeria