Frontiers in Genetics

Original Research

Accepted on 19 Dec 2025

DPCDI: An artificial intelligent-derived indicator interpreting the diagnostic, stratification, and therapeutic implications of druggability programmed cell death in heart failure

in RNA

Lili Zhang
Yihao Zhu
Yuan Fang
Yanping Yang
Yin Yu
Hanshi Wang
Xiyue Jiang
Xue Zhang
Dong Huang

Frontiers in Genetics

Editorial

Published on 16 Dec 2025

Editorial: A year in review: discussions in RNA

in RNA

Sybille Krauß
Nicoletta Potenza

Frontiers in Genetics

doi 10.3389/fgene.2025.1752525

705 views

Original Research

Published on 08 Dec 2025

Sex-specific circRNA–miRNA–mRNA networks in peripheral blood mononuclear cells of patients with idiopathic pulmonary arterial hypertension: a pilot study

in RNA

Yuan Li
Yuanyuan Sun
Yuxia Huang
Xiaoyi Hu
Ping Yuan

Frontiers in Genetics

doi 10.3389/fgene.2025.1674894

636 views

Review

Published on 27 Nov 2025

Biogenesis and function of circular RNAs and their implications in the Down syndrome brain

in RNA

Shahidee Zainal Abidin
Nurul Nadirah Razali
Pike-See Cheah
King-Hwa Ling

Frontiers in Genetics

doi 10.3389/fgene.2025.1708015

1,061 views

Original Research

Published on 26 Nov 2025

Identification and experimental validation of demethylation-related genes in diabetic nephropathy

in RNA

Hui Miao
Yunke Zhu
Jiaqi Zheng
Chunfeng Deng
Yi Zeng
Fei Tang
Xi Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1675592

1,310 views

Correction

Published on 24 Nov 2025

Correction: Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential

in RNA

Yubo Ren
Bomeng Zhao
Luo Lv
Jingyuan Yang
Xiangting Nan
Bao Li
Bin Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1746339

623 views

Review

Published on 24 Nov 2025

Circular RNAs at the crossroads of acute pancreatitis: bridging molecular mechanisms to diagnostic and therapeutic innovations

in RNA

Jing Chen
XiaoLing Chen
Fei He

Frontiers in Genetics

doi 10.3389/fgene.2025.1650363

808 views

Original Research

Published on 10 Nov 2025

Construction of a HSC activation-related lncRNA–miRNA–mRNA ceRNA regulatory network reveals potential molecules involved in liver fibrosis

in RNA

Kaiqiang Wan
Qiong Zhou
Ruirui Feng
Tao Liu
Chang Fan
Xue Pang
Zhongliang Li
Qiumei Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1640326

1,403 views

Original Research

Published on 07 Nov 2025

ST8SIA6-AS1 serves as a prognostic biomarker in cancer and exhibits oncogenic properties in prostate cancer

in RNA

Yaoan Wen
Jiangbin Yang
Shuyuan Zhan
Yuanjing Huang
Guoqiang Chen
Song Zheng
Shaoxing Zhu

Frontiers in Genetics

doi 10.3389/fgene.2025.1648077

1,229 views

Review

Published on 06 Nov 2025

Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential

in RNA

Yubo Ren
Bomeng Zhao
Luo Lv
Jingyuan Yang
Xiangting Nan
Bao Li
Bin Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1677797

1,836 views

Review

Published on 24 Oct 2025

Advances in RNA-based therapeutics: current breakthroughs, clinical translation, and future perspectives

in RNA

Sarbjeet Kaur Makkar

Frontiers in Genetics

doi 10.3389/fgene.2025.1675209

7,130 views
1 citation

Original Research

Published on 15 Oct 2025

Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cells

in RNA

Akito Yoshida
Yuqian Song
Hotaru Takaine
Sujin Song
Nonoka Konishi
Yu-Hsien Hwang-Fu
Zachary Johnson
Kiyoe Ura
Akira Sassa

Frontiers in Genetics

doi 10.3389/fgene.2025.1663827

13,863 views
1 citation

Review

Published on 14 Oct 2025

CircZFR functions in cancer from molecular networks to precision therapy

in RNA

Jinniang Nan
Min Li
Xinru Li
Yuqing Guo
Ziye Cai
Zekang Deng
Chengyi Zhan
Jiacheng Li
Shuying Liu
Ziyi Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1694220

1,861 views

Review

Published on 08 Oct 2025

NanoMarine therapeutics: a new wave in drug delivery from oceanic bioresources targeting colon cancer via miRNA modulation

in RNA

Ramkumar Muthu
Rajkumar Manickam
Rajkumar Thamarai
Sivabalan Sivasamy
Karthikeyan Mahendran
Rajkumar Prabhakaran

Frontiers in Genetics

doi 10.3389/fgene.2025.1668618

3,313 views

Original Research

Published on 08 Oct 2025

Modulation of the lncRNA TCONS_00265853-miR-421-5p-CLOCK axis by Ziyin Buyang Formula in polycystic ovarian syndrome with circadian rhythm disruption: an integrated bioinformatics and experimental approach

in RNA

Haixia Huang
Ling Sun
Fan Jia
Yong Tan
Yahong Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1658812

1,944 views

Mini Review

Published on 01 Oct 2025

Recent progress on DNA methylation in psoriasis

in RNA

Zhaoping Lin
Xiaoting Wu
Xuqin Hong
Dongying Luo
Hui Li
Fei Ma
Cong Huang
Bo Yu
Jing Gao
Changbing Shen

Frontiers in Genetics

doi 10.3389/fgene.2025.1681666

3,287 views

Original Research

Published on 29 Sep 2025

LncRNA and mRNA expression characteristic and bioinformatic analysis in anemic diabetic foot ulcers

in RNA

Jiayu Lin
Jingying Wang
Bo Liang

Frontiers in Genetics

doi 10.3389/fgene.2025.1603315

1,651 views

Review

Published on 24 Sep 2025

Mechanisms of circular RNAs in diabetic cardiomyopathy: biological characteristics and clinical prospects

in RNA

Yunfei Guan
Quancheng Han
Meng Wang
Jianguo Xu
Xiujuan Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1665571

3,104 views
1 citation

Original Research

Published on 08 Sep 2025

Constructing a neutrophil extracellular trap model based on machine learning to predict clinical outcomes and immune therapy responses in oral squamous cell carcinoma

in RNA

Jian Wang
Zhenzhen Li
Zhiwei Li
Zijing Yu
Wenpin Xu

Frontiers in Genetics

doi 10.3389/fgene.2025.1616868

3,465 views
1 citation

Review

Published on 08 Sep 2025

Mechanisms and recent advances in non-coding RNAs and RNA modifications in antiplatelet drug resistance

in RNA

Ping Ni
Kejie Chen
Jing Xiang
Haifeng Shao
Xiaoling Chen
Qiao Chen
Lingling Wang
Junli Hao
Xinyi Huang
Qing Cao

Frontiers in Genetics

doi 10.3389/fgene.2025.1618105

2,180 views

Original Research

Published on 03 Sep 2025

Integrating BERT pre-training with graph common neighbours for predicting ceRNA interactions

in RNA

Zhengxing Xie
Tianping Ying
Ge Jing
Shiyang Liang
Junhua Liu
Lianghua Tang

Frontiers in Genetics

doi 10.3389/fgene.2025.1606016

1,643 views

Data Report

Published on 01 Sep 2025

Data report: transcriptome profiling of 13 tissues of Junmu No. 1 boars

in RNA

Chunyan Bai
Jiayi Ning
Junwen Fei
Zhenbo Wang
Yu He
Jing Li
Xiaoran Zhang
Shuang Liang
Dali Wang
Hao Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1641395

2,191 views

Original Research

Published on 29 Aug 2025

Identification and experimental validation of circular RNA-associated ceRNA networks in intrauterine adhesion

in RNA

Yajie Chang
Rui Xiang
Qi Guo
Jing Li
Xiaolan Li
Zhi Zeng
Jintao Peng
Xiaoyan Liang

Frontiers in Genetics

doi 10.3389/fgene.2025.1619698

1,986 views

Original Research

Published on 21 Aug 2025

Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma

in RNA

Minglu Zhang
Jianbo He
Rao Fu
Guojian Bao
Yijun Lu
Zechuan Zhang
Jiawu Yan
Jialu Ding
Fei Yang
Beicheng Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1620552

2,681 views

1,379 articles

articles

DPCDI: An artificial intelligent-derived indicator interpreting the diagnostic, stratification, and therapeutic implications of druggability programmed cell death in heart failure

Editorial: A year in review: discussions in RNA

Sex-specific circRNA–miRNA–mRNA networks in peripheral blood mononuclear cells of patients with idiopathic pulmonary arterial hypertension: a pilot study

Biogenesis and function of circular RNAs and their implications in the Down syndrome brain

Identification and experimental validation of demethylation-related genes in diabetic nephropathy

Correction: Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential

Circular RNAs at the crossroads of acute pancreatitis: bridging molecular mechanisms to diagnostic and therapeutic innovations

Construction of a HSC activation-related lncRNA–miRNA–mRNA ceRNA regulatory network reveals potential molecules involved in liver fibrosis

ST8SIA6-AS1 serves as a prognostic biomarker in cancer and exhibits oncogenic properties in prostate cancer

Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential

Advances in RNA-based therapeutics: current breakthroughs, clinical translation, and future perspectives

Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cells

CircZFR functions in cancer from molecular networks to precision therapy

NanoMarine therapeutics: a new wave in drug delivery from oceanic bioresources targeting colon cancer via miRNA modulation

Modulation of the lncRNA TCONS_00265853-miR-421-5p-CLOCK axis by Ziyin Buyang Formula in polycystic ovarian syndrome with circadian rhythm disruption: an integrated bioinformatics and experimental approach

Recent progress on DNA methylation in psoriasis

LncRNA and mRNA expression characteristic and bioinformatic analysis in anemic diabetic foot ulcers

Mechanisms of circular RNAs in diabetic cardiomyopathy: biological characteristics and clinical prospects

Constructing a neutrophil extracellular trap model based on machine learning to predict clinical outcomes and immune therapy responses in oral squamous cell carcinoma

Mechanisms and recent advances in non-coding RNAs and RNA modifications in antiplatelet drug resistance

Integrating BERT pre-training with graph common neighbours for predicting ceRNA interactions

Data report: transcriptome profiling of 13 tissues of Junmu No. 1 boars

Identification and experimental validation of circular RNA-associated ceRNA networks in intrauterine adhesion

Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma