Frontiers in Genome Editing | Genome Editing in Animals

Original Research

Accepted on 11 Sep 2025

From GWAS Signal to Function: Targeted CRISPR Activation Enables Functional Characterization of Non-Coding SNPs in Chickens

in Genome Editing in Animals

Jaewon Kim
Jeong Hoon
Minjun Kim
Grace Schmidt
Eunjin Cho
Jun Heon Lee
Tae Hyun Kim

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1662152

325 views

Original Research

Published on 04 Jun 2025

Long read sequencing reveals transgene concatemerization and vector sequences integration following AAV-driven electroporation of CRISPR RNP complexes in mouse zygotes

in Genome Editing in Animals

Muhammad W. Luqman
Piroon Jenjaroenpun
Jessica Spathos
Nikhil Shingte
Mitchell Cummins
Pattaraporn Nimsamer
Lars M. Ittner
Thidathip Wongsurawat
Fabien Delerue

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1582097

3,105 views
1 citation

Methods

Published on 30 May 2025

Lentiviral CRISPRa/i in the adult prairie vole brain: modulating neuronal gene expression without DNA cleavage

in Genome Editing in Animals

Meredith K. Loth
Kendall T. Mesch
Celine Herrera-Garcia
Liza E. Brusman
Zoe R. Donaldson

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1602983

2,053 views
1 citation

Review

Published on 21 May 2025

Base editors in zebrafish: a new era for functional genomics and disease modeling

in Genome Editing in Animals

Yuwen Liu
Chao Li
Yiren Qiu
Sihong Chen
Yijun Luo
Donghua Xiong
Jun Zhao
Jianmin Ye
Xuegeng Wang
Wei Qin

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1598887

3,001 views
1 citation

Editorial

Published on 23 Jan 2025

Editorial: Insights in genome editing in animals 2023/2024

in Genome Editing in Animals

Gӧtz Laible
Mark Cigan

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1556425

2,933 views

Original Research

Published on 08 Jan 2025

Hyperthermia suppresses the biological characteristics and migration of chicken primordial germ cells

in Genome Editing in Animals

Yuzhou Gu
Kexin Wu
Bowen Niu
Zhiting Wang
Yuchen Jie
Zixuan Fan
Junying Li
Congjiao Sun
Zhuo-Cheng Hou
Li-Wa Shao

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1512108

2,252 views

Review

Published on 07 Jan 2025

Genetically modified chickens as bioreactors for protein-based drugs

in Genome Editing in Animals

Shujuan Meng
Aijun Miao
Sen Wu
Xuguang Du
Fei Gao

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1522837

5,324 views
2 citations

Review

Published on 24 Sep 2024

Global regulatory policies for animal biotechnology: overview, opportunities and challenges

in Genome Editing in Animals

Diane Wray-Cahen
Eric Hallerman
Mark Tizard

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1467080

11,685 views
12 citations

Systematic Review

Published on 13 Jun 2024

Horizon scanning of potential environmental applications of terrestrial animals, fish, algae and microorganisms produced by genetic modification, including the use of new genomic techniques

in Genome Editing in Animals

Marianne Miklau
Sarah-Joe Burn
Michael Eckerstorfer
Marion Dolezel
Anita Greiter
Andreas Heissenberger
Stefan Hörtenhuber
Werner Zollitsch
Kristin Hagen

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1376927

7,120 views
6 citations

Review

Published on 06 Jun 2024

A gene edited pig model for studying LGR5+ stem cells: implications for future applications in tissue regeneration and biomedical research

in Genome Editing in Animals

Amanda B. T. Hill
Yanet M. Murphy
Kathryn M. Polkoff
Laura Edwards
Derek M. Walker
Adele Moatti
Alon Greenbaum
Jorge A. Piedrahita

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1401163

3,829 views
2 citations

Original Research

Published on 31 May 2024

Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virus

in Genome Editing in Animals

Giovana Ciacci Zanella
Celeste A. Snyder
Bailey L. Arruda
Kristin Whitworth
Erin Green
Ravikanth Reddy Poonooru
Bhanu P. Telugu
Amy L. Baker

Frontiers in Genome Editing

doi 10.3389/fgeed.2023.1320180

4,197 views
4 citations

Original Research

Published on 13 Mar 2024

Pigs lacking the SRCR5 domain of CD163 protein demonstrate heritable resistance to the PRRS virus and no changes in animal performance from birth to maturity

in Genome Editing in Animals

Clint Nesbitt
Lucina Galina Pantoja
Benjamin Beaton
Ching-Yi Chen
Matt Culbertson
Perry Harms
Justin Holl
Andrzej Sosnicki
Srinu Reddy
Marisa Rotolo

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1322012

9,203 views
10 citations

Original Research

Published on 27 Nov 2023

Germline ablation achieved via CRISPR/Cas9 targeting of NANOS3 in bovine zygotes

in Genome Editing in Animals

Maci L. Mueller
Bret R. McNabb
Joseph R. Owen
Sadie L. Hennig
Alba V. Ledesma
Mitchell L. Angove
Alan J. Conley
Pablo J. Ross
Alison L. Van Eenennaam

Frontiers in Genome Editing

doi 10.3389/fgeed.2023.1321243

5,845 views
10 citations

Original Research

Published on 25 Oct 2023

Characterization of transcriptional enhancers in the chicken genome using CRISPR-mediated activation

in Genome Editing in Animals

Jeong Hoon Han
Hong Jo Lee
Tae Hyun Kim

Frontiers in Genome Editing

doi 10.3389/fgeed.2023.1269115

5,532 views

Mini Review

Published on 11 Oct 2023

How genome editing changed the world of large animal research

in Genome Editing in Animals

Konrad Fischer
Angelika Schnieke

Frontiers in Genome Editing

doi 10.3389/fgeed.2023.1272687

18,111 views
14 citations