Abstract
Psoriasis is a chronic, systemic, immune-mediated inflammatory disorder that is associated with a significantly increased risk of cardiovascular disease (CVD). Studies have shown that psoriasis often coexists with atherosclerosis, a chronic inflammatory disease of large and medium-sized arteries, which is a major cause of CVD. Although the molecular mechanisms underlying this comorbidity are not fully understood, clinical studies have shown that when interleukin (IL)-17A inhibitors effectively improve psoriatic lesions, atherosclerotic symptoms are also ameliorated in patients with both psoriasis and atherosclerosis. Also, IL-17A levels are highly expressed in the psoriatic lesions and atherosclerotic plaques. These clinical observations implicit that IL-17A could be a crucial link for psoriasis and atherosclerosis and IL-17A-induced inflammatory responses are the major contribution to the pathogenesis of comorbid psoriasis and atherosclerosis. In this review, the current literature related to epidemiology, genetic predisposition, and inflammatory mechanisms of comorbidity of psoriasis and atherosclerosis is summarized. We focus on the immunopathological effects of IL-17A in both diseases. The goal of this review is to provide the theoretical base for future preventing or treating psoriasis patients with atherosclerosis comorbidity. The current evidence support the notion that treatments targeting IL-17 seem to be hold some promise to reduce cardiovascular risk in patients with psoriasis.
1 Introduction
Psoriasis is a T cell-mediated inflammatory systemic disease mainly affecting the skin (1), which is characterized by a proliferation of keratinocytes and the appearance of erythematous plaques on the skin covered with white silver scales (2–4). Actually, psoriasis is not limited to the skin (5–7), and it also coexists with psoriatic arthritis, diabetes, depression, cardiovascular disease (CVD) and other diseases (8, 9). Among these diseases, CVD is the main cause of death in patients with psoriasis (9, 10). Comorbidity refers to the presence of one or more additional disorders that co-occur with the primary disease (11). Atherosclerosis, as a chronic inflammatory disease of large and medium-sized arteries, is a major cause of CVD (12). Patients suffering from comorbid psoriasis and atherosclerosis have brought a heavy burden to public health and health care system worldwide (5, 8). Although the mechanisms linking psoriasis with atherosclerosis are not well understood, it appears that over-activation of innate and adaptive immune responses is clearly involved in the two diseases (2, 13). Clinical research shows that the treatment of psoriasis with IL-17A inhibitors also reduces cardiovascular risk in patients with psoriasis (14, 15). Whether IL-17 is the pivotal factor for comorbid psoriasis and atherosclerosis needs to be clarified. Here we summarize the recent literature concerning the potential mechanisms of IL-17A that is involved in the comorbidity of psoriasis and atherosclerosis, thus providing a theoretical basis for IL-17A inhibitors treating patients with psoriasis and comorbid atherosclerotic disorders.
2 Epidemiology
2.1 Epidemiological Evidence in Comorbid Psoriasis and Atherosclerosis
Cumulative evidence shows that patients with psoriasis have a higher prevalence of cardiovascular events than healthy individuals at the same age (5). Dyslipidaemia is known to be one of the main risk factors for atherosclerosis (16). Epidemiological studies suggest a significant association between psoriasis and dyslipidaemia, with an odds ratio (OR) ranging from 1.04 to 5.55 (17–19). Patients with psoriasis had significantly lower levels of plasma high-density lipoprotein (HDL), and higher levels of total cholesterol, low-density lipoprotein (LDL), cholesterol, and triglycerides (TG) (20, 21), are similar to atherosclerosis. The patients with severe psoriasis are more likely to develop dyslipidaemia than patients with mild psoriasis (17). In addition, the prevalence of CVD was positively correlated with the severity of psoriatic lesions (5, 22). Patients with severe psoriasis had a 6.2% increased absolute risk of 10-year cardiovascular events compared to the age-matched health controls (23). If psoriasis was included to the Framingham cardiovascular risk score, most patients at low or moderate cardiovascular risk would be reclassified as being at moderate or high cardiovascular risk (24). Thus, psoriasis has been considered an independent risk factor for atherosclerosis, along with other conventional risk factors, such as smoking, hyperlipidaemia, diabetes, and hypertension (19, 25, 26).
2.2 Common Risk Factors in Comorbid Psoriasis and Atherosclerosis
Epidemiological studies have revealed that psoriasis and atherosclerosis share common external risk factors, which include smoking, alcohol abuse, sleep deprivation, environmental pollution, high-fat diets and psychological pressures (27, 28). Pathophysiologically, these risk factors activate the sympatho-adrenergic system, prolong an up-regulated reaction of the hypothalamic-pituitary-adrenal (HPA) axis, and promote endothelial dysfunction and lipid metabolism disorders (28, 29). These risk factors lead to systemically chronic inflammation that eventually contributes to development of both psoriasis and atherosclerosis (27–29).
Population-based prospective observational studies and randomized controlled trials also indicate some inherent risk factors that are common for both psoriasis and atherosclerotic disorders, such as hypertension, obesity, hyperlipidaemia and diabetes (28, 30, 31), of which obesity has more impact than other risk factors, because it also elevates the risk of diabetes (32, 33), hypertension (33–35), or dyslipidaemia (36, 37). Thus, obesity, a chronic metabolic disease, is the main factor in the association between psoriasis and CVD (38). The excessive accumulation of fat and abnormal fat distribution in the body is the consequence of inflammation and insulin resistance (39). Obesity is often accompanied by high levels of total cholesterol, TG, LDL, ultra-low-density lipoprotein (ULDL), and lipoproteins, as well as decreased levels of HDL and apolipoprotein B (ApoB) (40). In addition, adipokines are highly expressed in obese patients such as adiponectin, omentin, leptin, resistin, visfatin, retinol binding protein 4 (RBP4) and other chemo-attractants (41–43). All the adipokines, except adiponectin and omentin, appear to be involved in the pathogenic process of comorbid psoriasis and atherosclerosis by activating Th17 cells to secrete IL-17 (42–45).
3 Common Pathogenesis of Psoriasis and Atherosclerosis
3.1 Genetic Susceptibility
The common pathogenic mechanisms linking psoriasis and atherosclerosis are possibly driven by specific hub genes (46). Lu et al. noted the genetic similarity between psoriasis and CVD using single-nucleotide polymorphisms (SNPs) as risk indicators for CVD and psoriasis (46). Using the cyto-Hubba method, studies have recently identified 16 hub genes associated with these two diseases, in which 7 genes (MMP9, CSF2RB, IL1RN, CCL5, CD53, NCF2 and TLR2) are upregulated in both psoriasis and atherosclerosis (47). Among them, the function of MMP9 gene is more closely related to IL-17 as IL-17 inhibitors can reduce the expression of MMP9 (48), and level of MMP9 has been also associated with chronic progress of psoriasis (49, 50). Therefore, the pathogenic mechanisms of comorbid psoriasis and atherosclerosis are likely controlled by these hub genes (47). Animal models with gene knout out may be able to verify such comorbidity mechanisms at a genetic perspective.
3.2 Inflammatory Mechanism
3.2.1 IL-17 Serves as a Key Mediator in Comorbid Psoriasis and Atherosclerosis
3.2.1.1 The IL-17 Cytokine Family
IL-17 is a main pro-inflammatory cytokine mainly produced by Th17 cells, which plays a crucial role in the pathogenesis of various inflammatory diseases, including psoriasis and atherosclerosis (51). The IL-17 cytokine family has six members (IL-17A to IL-17F) (52), of which IL-17A has the highest biological activity (53). Psoriatic lesions are characterized by high expression levels of IL-17A and IL-17F, which are responsible for tissue inflammation by recruiting neutrophils and forming micro-abscesses on the sites (54–56). In addition to IL-17A (57) and IL-17F (58), IL-17C (59, 60) and IL-17E (61, 62) can also aggravate psoriatic lesions; meanwhile, IL-17A and IL-17C can enhance atherosclerotic plaque instability, and IL-17E is protective against atherosclerosis (63, 64). However, the role of IL-17F in CVD has not yet been well investigated. The transcript levels of other two IL-17 subtypes, IL-17B and IL-17D, are reduced in psoriatic lesions (65), but the effects of IL-17B and IL-17D in atherosclerosis are unknown. These data indicate that the high levels of IL-17A and IL-17C may be more important in terms of disease development and progress in psoriatic lesions and atherosclerotic plaque. Figure 1 shows the roles of IL-17 in both psoriasis and atherosclerosis (66). Heterodimeric receptors consisting of different members of the IL-17R family (IL-17RA to IL-17RE) activate the IL-17 signaling pathway upon binding to IL-17 (66). All subunits of the IL-17R family have a widespread expression pattern, with IL-17RA being ubiquitous (53, 66).
Figure 1
It is well known that IL-17 family members, especially IL-17A, play a critical role in psoriasis by activating other relevant cells to be involved in inflammatory response. It has been demonstrated that IL-17A can induce the proliferation of keratinocytes (67). In addition, it also targets other cell types, including endothelial cells, fibroblasts, chondrocytes and synovial cells, which may explain the IL-17A involvement in CVD (66, 68, 69). Thus, our discussion will focus on the role of IL-17A in comorbid psoriasis and atherosclerosis.
IL-17A is largely derived from Th17 cells that reside in lymphoid organs at a state of homeostasis but move into peripheral tissues in course of inflammation (70, 71). Peripheral organs, particularly mucous membranes and skin tissues, are the second major source of Th17 cells (70). Differentiation of Th17 cells requires the key transcription factor ROR-γt (retinoid-related orphan receptor) (72) in combination with other transcription factors, such as ROR-α, signal transducers, and transcriptional activators 3 (STAT3) (73, 74). At the same time, Th17 cells also highly express IL-23R for binding of IL-23, which amplifies Th17 cell proliferation and survival resulting in further IL-17 production (75). A microenvironment composed of transforming growth factor (TGF)-β and inflammatory cytokines IL-6, IL-21, IL-1β and IL-23 has been considered to play a central role in the proliferation and maintenance of Th17 cells as well (76). For example, highly expressed RORγt in γδ T cells, together with IL-23R and C-C chemokine receptor type 6 (CCR6), can significantly promote the production of IL-17A (77, 78).
In addition to Th17 cells, other immune cell types (e.g., γδ T cells and mast cells) can also produce IL-17A that accounts for a small proportion of IL-17A production. Two types of immune cells are responsible for IL-17A production: one is thymus-dependent cells type that includes CD8 T cells, γδ T cells and invariant NKT (iNKT) cells, and the other type is thymus-independent cells, including group 3 innate lymphoid cells (ILC), mast cells, and neutrophils (66, 79).
3.2.1.2 IL-17 Is a Key Link in the Pathogenesis of Comorbid Psoriasis and Atherosclerosis
Studies using psoriasis-like animal models induced by air-pouch (80) or imiquimod (81) confirmed that psoriasis was elicited by the IL-23/IL-17 axis. Naive T cells are differentiated into Th1 cells by IL-12 and interferon (IFN)-γ or Th17 cells by IL-6, TGF-β and IL-23 respectively (82, 83). In psoriatic lesions, the activated Th1 cells produce large amount of tumor necrosis factor-alpha (TNF-α) and IFN-γ, which contribute to activation and proliferation of keratinocytes and subsequent expression of intercellular adhesion molecule 1 (ICAM-1) (84). ICAM-1 is bound to T cells to accelerate the migration of T cells, including Th17 subsets, into the dermis that gradually aggravates inflammation in psoriatic lesions (85). Increased ROR-γt expression and decreased Foxp3 expression in IL-17-expressing T cells then stimulate pro-inflammatory signaling, ultimately resulting in the activation and proliferation of keratinocytes in the skin (86). Activated Th17 cells secrete IL-22 and IL-17, which primarily promote the proliferation of keratinocytes to exacerbate inflammatory lesions. It is quite possible that IL-17 synergizes with TNF-α to promote the angiogenesis that is present in the psoriatic lesions (85, 87, 88).
Compared with psoriasis, the pathogenic effects of Th17 cells in atherosclerosis may rely more on the cytokines in microenvironment. Many previous studies have shown that nuclear factor (NF-kB) signaling pathway could be responsible for such proatherogenic effects of IL-17 (89, 90). Taleb et al. found that the dual production of IL-17 and IFN-γ would promote the atherosclerotic plaques instability, which could be also resulted from a decreased Treg cells by altered levels of TGF-β (91, 92). Actually, TGF-β3, drives a pathogenic Th17 phenotype by inducing IL-17A/IFN-γ double producing cells in an IL-23-dependent manner (93, 94). Dual production of IL-17 and IFN-γ will contribute significantly to the development of atherosclerotic plaques and increase plaque instability (91). Other studies found that increased level of circulating Th17 cells and Th17-associated cytokines is correlated with the severity and progression of carotid artery plaques in the presence of high IFN- γ milieu (95). In addition, IFN-γ, the landmark cytokine of Th1 cells, also plays an important role in atherosclerosis (96). Raymond et al. showed that IL-17, together with the IL-12/IFN-γ axis (Th1 cells related), can be detected in coronary artery-infiltrating T cells of human atherosclerotic plaques, suggesting infiltrating T cells can produce both IL-17 and IFN-γ. Nevertheless, IL-17 and IFN-γ exert synergistic pro-inflammatory rather than antagonistic effects, which can be observed in vascular smooth muscle cells in in vitro experiments (96–98). IL-17 can induce the expression of matrix metalloproteinase (MMP) and proinflammatory cytokines such as TNF-α, IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF), chemokines (CCL2, CXCL1, CXCL8, and CXCL10) in endothelial cells, smooth muscle cells, and macrophages to recruit neutrophils and monocytes into the plaques (99, 100). In atherosclerosis, endothelial cell activation at sites of nascent arterial plaque promotes monocyte and lymphocyte infiltration and subsequent activates macrophage and dendritic cell to secrete IL-12 and IL-23. Differentiated Th1 cells further promote atherosclerotic plaque growth, while Th17 cells enhance intraplaque neoangiogenesis and intraplaque hemorrhage (101). In addition, increased level of intraplaque IL-17 may further weaken the fibrous caps followed by plaque rupture (5, 92) (Figure 2).
Figure 2
Taken together, current evidence suggests that psoriasis and atherosclerosis may share common immunopathogenic mechanisms via the IL-23/IL-17 axis (18, 51). However, some studies also show that IL-17 plays a role in promoting the stabilization of atherosclerotic plaques (99, 100). It is believed that IL-17 maintains plaque stability by down-regulating VCAM-1 expression on endothelial cells and preventing T-cell infiltration into plaques, which in turn reduces inflammatory cytokines such as IFN-γ secretion and increases anti-inflammatory cytokines IL-5, IL-10, and TGF-β levels (18). Taleb et al. also proved that increased IL-10-producing Treg cells probably promote plaque stability (91). Increased levels of Treg cells promote conversion to TGF-β1, which is a TGF-β isoform in the generation of non-pathogenic Th17 cells (18). While the combination of TGF-β1 and IL-6 promotes the differentiation of Treg cells, the subsequent IL-10 provides anti-inflammatory and immune regulatory properties (102). The role of IL-17 in promoting either plaque instability or stability in atherosclerosis mainly depends on the inflammatory microenvironment that consists of Treg cells and cytokines. Current evidence tends to support the view that IL-17 exerts mainly pro-inflammatory role in the comorbid psoriasis and atherosclerosis.
3.2.2 IL-17 Effects on Psoriasis and Atherosclerosis Can Be Enhanced by IFN-γ and TNF-α
The link between psoriasis and atherosclerosis has been proposed as “one syndrome and two plaques” (103, 104) to reflect the similar inflammatory cytokine profiles of the two diseases, including TNF-α, IFN-γ, IL-1, IL-6, IL-8, IL-12, IL-17, IL-20 and IL-23 (105), of which a synergistic effect of IFN-γ and TNF-α on the immunopathogenic mechanism has been noted in comorbid atherosclerosis and psoriasis (97).
Studies have shown that both IFN-γ and TNF-α cytokines are increased in the serum of patients with psoriasis and their respective receptors are increased in atherosclerosis (97). Elevated levels of IFN-γ and TNF-α, increased T-cell chelators and adhesion molecules, and progressive loss of endothelial barrier integrity are observed during atherosclerosis formation, both in vivo and in vitro experiments (97). Thus, the dual role of TNF-α/IFN-γ, especially TNF-α, also contributes significantly to psoriatic lesion inflammation and atherosclerosis formation (97). TNF-α, together with IL-17 in the IL-23/IL-17 axis at the core of pathogenesis, exerts a proinflammatory effect by promoting the maturation of myeloid dendritic cells (106, 107).
3.2.3 Other cytokines and Chemokines Involved in Function of IL-17
In addition to TNF-α/IFN-γ and IL-23, many other chemokines and cytokines may contribute to the inflammatory process in comorbidity. It is worth noting that vascular endothelial growth factor (VEGF), IL-12 and monocyte chemotaxis protein 1 (MCP-1) are all strongly involved in the pathogenesis and development of both psoriasis and atherosclerosis (47). IL-17 could interact with its target cells such as keratinocytes and endothelial cells in a feedback loop manner (108). In the pathogenesis of psoriasis, IL-17 interacts with keratinocytes to promote the production of antimicrobial peptides, proinflammatory cytokines and chemokines (IL-1β, TNF-α, IL-6, IL-17C, CXCL1, CXCL3, CXCL5, CXCL8 [IL-8] and CCL20) and proliferative cytokines (IL-19) (55, 109, 110). IL-17 may promote endothelial inflammation via upregulating cytokines such as IL-6, IL-8 and ICAM-1, which in turn further promotes IL-17 production in a feedback loop for acceleration of the atherosclerotic plaque formation (109).
4 Pathophysiological Changes in Psoriasis and Atherosclerosis
Pathophysiologically, atherosclerosis and psoriasis share some common aspects. The infiltration of T cells, macrophages, monocytes, lymphocytes and dendritic cells are demonstrated in the psoriatic lesions and atherosclerotic plaques (105). In both diseases, inflammatory conditions could be an immune response for the locally formed autoantigens. These autoantigens stimulate both the innate and adaptive immune system for a T cell response (111).
As the key linker, IL-17 directly or indirectly mediates multiple steps of the immune signaling cascades (112, 113). In psoriatic inflammation, IL-17 drives the secretion of several key proinflammatory cytokines such as IL-1β, CCL20 and antimicrobial peptides, which can attract neutrophils, dendritic cells and T cells into psoriatic lesions (114). Histologically, the typical features of human psoriasis include hyperkeratosis, acanthosis, and infiltration of Th17 cells and neutrophils. In mouse psoriasis models, IL-17A released from skin-infiltrating T cells has been demonstrated to increase neutrophil recruitment (115, 116). An IL-17A dominance has also been shown in human psoriasis cases (117). Atherosclerosis is a complex inflammatory disease of the arterial wall that could be initiated by a variety of pro-atherogenic stimuli such as ox-LDL (118), and even represents autoimmune response. Microenvironment consisting of the aforementioned cytokines and chemokines is formed in the arterial endothelium after ox-LDL stimulation, in which monocytes and smooth muscle cells are infiltrated as atherosclerosis progresses (119). Increased blood flow and adhesion molecules induce migration of inflammatory cells into the vessel wall (2, 120). As a result, T cells-mediated adaptive immune response increases the number of arterial foam cells derived from macrophages and monocytes (121).
5 Treatments
Anti-inflammatory therapies directly or indirectly targeting IL-17A in patients with psoriasis are already available (122). IL-17 inhibitors are widely used in the treatment of psoriasis, especially in patients with moderate-to-severe psoriasis (122). IL-17A inhibitors can significantly improve the psoriatic lesions and pruritic symptoms of psoriasis patients (123). Upstream inflammatory factor inhibitors, such as TNF-α antagonists, significantly reduce the risk of CVD in psoriasis patients by reducing vascular inflammation, endothelial dysfunction, and arterial hypertension (97, 124). Some randomized clinical trials also revealed that secukinumab, a fully human monoclonal antibody against IL-17A, has a beneficial effect on CVD risk by promoting the endothelial function of plaque stability in psoriasis patients without CVD (15) and exhibits a neutral impact on aortic vascular inflammation and biomarkers of CVD (125). Clinically, the cardiovascular side effect of IL-17 inhibitors appears to be minimal, and IL-17 monoclonal antibodies improve outcomes of patients with psoriasis comorbid CVD by preventing lesion progression and sustaining plaque stabilization (126). In the same fashion, neutralization of cytokines downstream of IL-17A has been demonstrated to improve vascular health in a murine IL-17A over-expressed model (124). Anti-IL-17A monoclonal antibodies can prevent vascular disease in a mouse model of psoriasis, which will be the subject of future research focus (126). Other observational studies also support those systemic anti-inflammatory treatments may represent alternative approaches for the treatment of patients with comorbid psoriasis and atherosclerosis (127).
6 Conclusion
Current evidence from immunopathological studies has suggested that IL-17 and the IL-23/IL-17 axis may play a pivotal role in linking the comorbid psoriasis and atherosclerosis. Indeed, clinical trials have confirmed a decreased risk of early CVD indicators in psoriasis patients treated with IL-17 inhibitors. Thus, biological agents targeting IL-17A signaling pathway are expected to be widely used in the treatment of two comorbid diseases. While IL-17 promotes the proliferation of keratinocytes in psoriatic inflammatory lesions, its role in stabilizing or promoting plaque in atherosclerosis is still controversial. Current studies tend to support the pro-inflammatory pathogenic role of IL-17 in the comorbid psoriasis and atherosclerosis. A further characterization of different T cell subsets such as Treg cells in the course of both inflammatory diseases would provide new insights for future development of novel treatments.
However, it is worth to note that environmental pollution and poor lifestyle habits like smoking, alcohol abuse, sleep deprivation and psychological pressures are common external risk factors for both psoriasis and atherosclerosis. However, there is no literature indicating that poor lifestyle habits and adverse environments are linked with psoriasis and atherosclerosis through IL-17, which deserves further exploration. Clinically, patients with psoriasis, especially plaque psoriasis, who also suffer from the underlying diseases such as obesity, hyperlipidemia, diabetes, hypertension, and mental illnesses (e.g., anxiety and depression) should be routinely recommended for further assessments of cardiovascular risk.
7 Future Clinical Perspectives
Clinically, it has been proved that IL-17 inhibitors significantly improve the severity of psoriatic skin lesions and comorbid atherosclerotic plaques in psoriasis patients. The scientific community may pay more attention to the “plaque parallelism” of comorbid psoriasis and atherosclerosis, especially in plaque psoriasis. In view of the possible central role of IL-17 in the inflammatory pathway, future studies could shift the focus from IL-17 to its upstream and downstream related molecules, such as IL-6, to explore potential diagnostic biomarkers and targets of therapies for cardiovascular events in psoriasis patients.
Funding
This work was supported in part by grants from the National Natural Science Foundation of China (NM 81773337), the Key Research and Development Plan of Shandong Province (NM2019GSF108191) and the Traditional Chinese Medicine Science and Technology Program of Shandong Province (NM 2021M080).
Publisher’s Note
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Statements
Author contributions
DS and ZY: conception of the work. YW, CL and DS: extensive literature search and manuscript drafting. YW, JZ and CL: creating the cartoons. DS, ZY and YW: critical revision of the work and final version approval. All authors contributed to the article and approved the submitted version.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
1
MiddeHSPriyadarssiniMRajappaMMunisamyMMohan RajPSSinghSet al. Interleukin-9 Serves as a Key Link Between Systemic Inflammation and Angiogenesis in Psoriasis. Clin Exp Dermatol (2021) 46(1):50–7. doi: 10.1111/ced.14335
2
BoehnckeW-HSchönMP. Psoriasis. Lancet (2015) 386(9997):983–94. doi: 10.1016/s0140-6736(14)61909-7
3
RendonASchakelK. Psoriasis Pathogenesis and Treatment. Int J Mol Sci (2019) 20(6):1475. doi: 10.3390/ijms20061475
4
ChongHTKopeckiZCowinAJ. Lifting the Silver Flakes: The Pathogenesis and Management of Chronic Plaque Psoriasis. BioMed Res Int (2013) 2013:168321. doi: 10.1155/2013/168321
5
LockshinBBalagulaYMerolaJF. Interleukin 17, Inflammation, and Cardiovascular Risk in Patients With Psoriasis. J Am Acad Dermatol (2018) 79(2):345–52. doi: 10.1016/j.jaad.2018.02.040
6
KovitwanichkanontTChongAHFoleyP. Beyond Skin Deep: Addressing Comorbidities in Psoriasis. Med J Aust (2020) 212(11):528–34. doi: 10.5694/mja2.50591
7
ReichK. The Concept of Psoriasis as a Systemic Inflammation: Implications for Disease Management. J Eur Acad Dermatol Venereol (2012) 26 Suppl 2:3–11. doi: 10.1111/j.1468-3083.2011.04410.x
8
GriffithsCEMArmstrongAWGudjonssonJEBarkerJNWN. Psoriasis. Lancet (2021) 397(10281):1301–15. doi: 10.1016/s0140-6736(20)32549-6
9
DaudenECastanedaSSuarezCGarcia-CampayoJBlascoAJAguilarMDet al. Clinical Practice Guideline for an Integrated Approach to Comorbidity in Patients With Psoriasis. J Eur Acad Dermatol Venereol (2013) 27(11):1387–404. doi: 10.1111/jdv.12024
10
ManolisAAManolisTAMelitaHManolisAS. Psoriasis and Cardiovascular Disease: The Elusive Link. Int Rev Immunol (2019) 38(1):33–54. doi: 10.1080/08830185.2018.1539084
11
HeFZhuGWangYYZhaoXMHuangDS. PCID: A Novel Approach for Predicting Disease Comorbidity by Integrating Multi-Scale Data. IEEE/ACM Trans Comput Biol Bioinform (2017) 14(3):678–86. doi: 10.1109/TCBB.2016.2550443
12
EngelenSERobinsonAJBZurkeYXMonacoC. Therapeutic Strategies Targeting Inflammation and Immunity in Atherosclerosis: How to Proceed? Nat Rev Cardiol (2022) 1–21. doi: 10.1038/s41569-021-00668-4
13
RoyPOrecchioniMLeyK. How the Immune System Shapes Atherosclerosis: Roles of Innate and Adaptive Immunity. Nat Rev Immunol (2021) 22(4):251–65. doi: 10.1038/s41577-021-00584-1
14
MarovtMMarkoPBPirnatMEkartR. Effect of Biologics Targeting Interleukin-23/-17 Axis on Subclinical Atherosclerosis: Results of a Pilot Study. Clin Exp Dermatol (2020) 45(5):560–4. doi: 10.1111/ced.14180
15
von StebutEReichKThaciDKoenigWPinterAKorberAet al. Impact of Secukinumab on Endothelial Dysfunction and Other Cardiovascular Disease Parameters in Psoriasis Patients Over 52 Weeks. J Invest Dermatol (2019) 139(5):1054–62. doi: 10.1016/j.jid.2018.10.042
16
ZaricBObradovicMTrpkovicABanachMMikhailidisDPIsenovicER. Endothelial Dysfunction in Dyslipidaemia: Molecular Mechanisms and Clinical Implications. Curr Med Chem (2020) 27(7):1021–40. doi: 10.2174/0929867326666190903112146
17
MaCHarskampCTArmstrongEJArmstrongAW. The Association Between Psoriasis and Dyslipidaemia: A Systematic Review. Br J Dermatol (2013) 168(3):486–95. doi: 10.1111/bjd.12101
18
EgebergAGisondiPCarrascosaJMWarrenRBMrowietzU. The Role of the Interleukin-23/Th17 Pathway in Cardiometabolic Comorbidity Associated With Psoriasis. J Eur Acad Dermatol Venereol (2020) 34(8):1695–706. doi: 10.1111/jdv.16273
19
GisondiPBellinatoFGirolomoniGAlbanesiC. Pathogenesis of Chronic Plaque Psoriasis and Its Intersection With Cardio-Metabolic Comorbidities. Front Pharmacol (2020) 11:117. doi: 10.3389/fphar.2020.00117
20
PietrzakAMichalak-StomaAChodorowskaGSzepietowskiJC. Lipid Disturbances in Psoriasis: An Update. Mediators Inflamm (2010) 2010:535612. doi: 10.1155/2010/535612
21
AshaKSingalASharmaSBAroraVKAggarwalA. Dyslipidaemia & Oxidative Stress in Patients of Psoriasis: Emerging Cardiovascular Risk Factors. Indian J Med Res (2017) 146(6):708–13. doi: 10.4103/ijmr.IJMR_717_16
22
ArmstrongAWHarskampCTLedoLRogersJHArmstrongEJ. Coronary Artery Disease in Patients With Psoriasis Referred for Coronary Angiography. Am J Cardiol (2012) 109(7):976–80. doi: 10.1016/j.amjcard.2011.11.025
23
MehtaNNYuYPinnelasRKrishnamoorthyPShinDBTroxelABet al. Attributable Risk Estimate of Severe Psoriasis on Major Cardiovascular Events. Am J Med (2011) 124(8):775e1–6. doi: 10.1016/j.amjmed.2011.03.028
24
MehtaNNKrishnamoorthyPYuYKhanORaperAVan VoorheesAet al. The Impact of Psoriasis on 10-Year Framingham Risk. J Am Acad Dermatol (2012) 67(4):796–8. doi: 10.1016/j.jaad.2012.05.016
25
ChoiBGKimMJYangHSLeeYWChoeYBAhnKJ. Assessment of Arterial Stiffness in Korean Patients With Psoriasis by Cardio-Ankle Vascular Index. Angiology (2017) 68(7):608–13. doi: 10.1177/0003319716652284
26
LaiYCYewYW. Psoriasis as an Independent Risk Factor for Cardiovascular Disease: An Epidemiologic Analysis Using a National Database. J Cutan Med Surg (2016) 20(4):327–33. doi: 10.1177/1203475415602842
27
Rafieian-Kopaei.MSetorkiMDoudiMBaradaranANasriH. Atherosclerosis: Process, Indicators, Risk Factors and New Hopes. Int J Prev Med (2014) 5(8):927–46
28
KamiyaKKishimotoMSugaiJKomineMOhtsukiM. Risk Factors for the Development of Psoriasis. Int J Mol Sci (2019) 20(18):4347. doi: 10.3390/ijms20184347
29
LechnerKvon SchackyCMcKenzieALWormNNixdorffULechnerBet al. Lifestyle Factors and High-Risk Atherosclerosis: Pathways and Mechanisms Beyond Traditional Risk Factors. Eur J Prev Cardiol (2020) 27(4):394–406. doi: 10.1177/2047487319869400
30
SpahF. Inflammation in Atherosclerosis and Psoriasis: Common Pathogenic Mechanisms and the Potential for an Integrated Treatment Approach. Br J Dermatol (2008) 159 Suppl 2:10–7. doi: 10.1111/j.1365-2133.2008.08780.x
31
KimNThrashBMenterA. Comorbidities in Psoriasis Patients. Semin Cutan Med Surg (2010) 29(1):10–5. doi: 10.1016/j.sder.2010.01.002
32
Prospective StudiesC. Body-Mass Index and Cause-Specific Mortality in 900 000 Adults: Collaborative Analyses of 57 Prospective Studies. Lancet (2009) 373(9669):1083–96. doi: 10.1016/s0140-6736(09)60318-4
33
FallTHaggSMagiRPlonerAFischerKHorikoshiMet al. The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PloS Med (2013) 10(6):e1001474. doi: 10.1371/journal.pmed.1001474
34
LookARGWingRRBolinPBrancatiFLBrayGAClarkJMet al. Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes. N Engl J Med (2013) 369(2):145–54. doi: 10.1056/NEJMoa1212914
35
ChenZSmithMDuHGuoYClarkeRBianZet al. Blood Pressure in Relation to General and Central Adiposity Among 500 000 Adult Chinese Men and Women. Int J Epidemiol (2015) 44(4):1305–19. doi: 10.1093/ije/dyv012
36
JungUChoiM-S. Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship Between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease. Int J Mol Sci (2014) 15(4):6184–223. doi: 10.3390/ijms15046184
37
KlopBElteJWCabezasMC. Dyslipidemia in Obesity: Mechanisms and Potential Targets. Nutrients (2013) 5(4):1218–40. doi: 10.3390/nu5041218
38
ArmstrongAWHarskampCTArmstrongEJ. Psoriasis and Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies. J Am Acad Dermatol (2013) 68(4):654–62. doi: 10.1016/j.jaad.2012.08.015
39
MendisSDavisSNorrvingB. Organizational Update: The World Health Organization Global Status Report on Noncommunicable Diseases 2014; One More Landmark Step in the Combat Against Stroke and Vascular Disease. Stroke (2015) 46(5):e121–2. doi: 10.1161/STROKEAHA.115.008097
40
PraveenkumarUGangulySRayLNandaSKKuruvilaS. Prevalence of Metabolic Syndrome in Psoriasis Patients and its Relation to Disease Duration: A Hospital Based Case-Control Study. J Clin Diagn Res (2016) 10(2):WC01–5. doi: 10.7860/JCDR/2016/17791.7218
41
CorbiGPolitoRMonacoMLCacciatoreFScioliMFerraraNet al. Adiponectin Expression and Genotypes in Italian People With Severe Obesity Undergone a Hypocaloric Diet and Physical Exercise Program. Nutrients (2019) 11(9):2195. doi: 10.3390/nu11092195
42
WeschenfelderCSchaan de QuadrosALorenzon Dos SantosJBueno GarofalloSMarcadentiA. Adipokines and Adipose Tissue-Related Metabolites, Nuts and Cardiovascular Disease. Metabolites (2020) 10(1):32. doi: 10.3390/metabo10010032
43
ZorenaKJachimowicz-DudaOSlezakDRobakowskaMMrugaczM. Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications. Int J Mol Sci (2020) 21(10):3570. doi: 10.3390/ijms21103570
44
ShibataSTadaYHauCSMitsuiAKamataMAsanoYet al. Adiponectin Regulates Psoriasiform Skin Inflammation by Suppressing IL-17 Production From Gammadelta-T Cells. Nat Commun (2015) 6:7687. doi: 10.1038/ncomms8687
45
BaranAFlisiakIJaroszewiczJSwiderskaM. Effect of Psoriasis Activity on Serum Adiponectin and Leptin Levels. Postepy Dermatol Alergol (2015) 32(2):101–6. doi: 10.5114/pdia.2014.40960
46
LuYChenHNikamoPQi LowHHelmsCSeielstadMet al. Association of Cardiovascular and Metabolic Disease Genes With Psoriasis. J Invest Dermatol (2013) 133(3):836–9. doi: 10.1038/jid.2012.366
47
SuWZhaoYWeiYZhangXJiJYangS. Exploring the Pathogenesis of Psoriasis Complicated With Atherosclerosis via Microarray Data Analysis. Front Immunol (2021) 12:667690. doi: 10.3389/fimmu.2021.667690
48
ObradovicHKrsticJKukoljTTrivanovicDDordevicIOMojsilovicSet al. Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK1/2 Activation: Implications in Myogenic Differentiation. Mediators Inflamm (2016) 2016:2939658. doi: 10.1155/2016/2939658
49
GlazewskaEKNiczyporukMLawickiSSzmitkowskiMDonejkoMZajkowskaMet al. Narrowband Ultraviolet B Light Treatment Changes Plasma Concentrations of MMP-3, MMP-9 and TIMP-3 in Psoriatic Patients. Ther Clin Risk Manag (2017) 13:575–82. doi: 10.2147/TCRM.S125595
50
WangXLiuXLiuNChenH. Prediction of Crucial Epigeneticallyassociated, Differentially Expressed Genes by Integrated Bioinformatics Analysis and the Identification of S100A9 as a Novel Biomarker in Psoriasis. Int J Mol Med (2020) 45(1):93–102. doi: 10.3892/ijmm.2019.4392
51
LiuTLiSYingSTangSDingYLiYet al. The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside. Front Immunol (2020) 11:594735. doi: 10.3389/fimmu.2020.594735
52
GaffenSL. Life Before Seventeen: Cloning of the IL-17 Receptor. J Immunol (2011) 187(9):4389–91. doi: 10.4049/jimmunol.1102576
53
GaffenSL. Recent Advances in the IL-17 Cytokine Family. Curr Opin Immunol (2011) 23(5):613–9. doi: 10.1016/j.coi.2011.07.006
54
SenraLMylonasAKavanaghRDFallonPGConradCBorowczyk-MichalowskaJet al. IL-17e (IL-25) Enhances Innate Immune Responses During Skin Inflammation. J Invest Dermatol (2019) 139(8):1732–42.e17. doi: 10.1016/j.jid.2019.01.021
55
HarperEGGuoCRizzoHLillisJVKurtzSESkorchevaIet al. Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis. J Invest Dermatol (2009) 129(9):2175–83. doi: 10.1038/jid.2009.65
56
WilsonNJBonifaceKChanJRMcKenzieBSBlumenscheinWMMattsonJDet al. Development, Cytokine Profile and Function of Human Interleukin 17-Producing Helper T Cells. Nat Immunol (2007) 8(9):950–7. doi: 10.1038/ni1497
57
SpeeckaertRLambertJGrineLVan GeleMDe SchepperSvan GeelN. The Many Faces of Interleukin-17 in Inflammatory Skin Diseases. Br J Dermatol (2016) 175(5):892–901. doi: 10.1111/bjd.14703
58
SoderstromCBersteinGZhangWValdezHFitzLKuhnMet al. Ultra-Sensitive Measurement of IL-17A and IL-17F in Psoriasis Patient Serum and Skin. AAPS J (2017) 19(4):1218–22. doi: 10.1208/s12248-017-0094-4
59
VandeghinsteNKlattigJJagerschmidtCLavazaisSMarsaisFHaasJDet al. Neutralization of IL-17c Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis. J Invest Dermatol (2018) 138(7):1555–63. doi: 10.1016/j.jid.2018.01.036
60
ButcherMJWaseemTCGalkinaEV. Smooth Muscle Cell-Derived Interleukin-17c Plays an Atherogenic Role via the Recruitment of Proinflammatory Interleukin-17a+ T Cells to the Aorta. Arterioscler Thromb Vasc Biol (2016) 36(8):1496–506. doi: 10.1161/ATVBAHA.116.307892
61
SenraLStalderRAlvarez MartinezDChizzoliniCBoehnckeWHBrembillaNC. Keratinocyte-Derived IL-17e Contributes to Inflammation in Psoriasis. J Invest Dermatol (2016) 136(10):1970–80. doi: 10.1016/j.jid.2016.06.009
62
SutoHNambuAMoritaHYamaguchiSNumataTYoshizakiTet al. IL-25 Enhances TH17 Cell-Mediated Contact Dermatitis by Promoting IL-1beta Production by Dermal Dendritic Cells. J Allergy Clin Immunol (2018) 142(5):1500–9.e10. doi: 10.1016/j.jaci.2017.12.1007
63
MantaniPTDunerPBengtssonELjungcrantzISundiusLToFet al. Interleukin-25 (IL-25) has a Protective Role in Atherosclerosis Development in the Aortic Arch in Mice. J Biol Chem (2018) 293(18):6791–801. doi: 10.1074/jbc.RA117.000292
64
MantaniPTDunerPBengtssonEAlmRLjungcrantzISoderbergIet al. IL-25 Inhibits Atherosclerosis Development in Apolipoprotein E Deficient Mice. PloS One (2015) 10(1):e0117255. doi: 10.1371/journal.pone.0117255
65
JohansenCUsherPAKjellerupRBLundsgaardDIversenLKragballeK. Characterization of the Interleukin-17 Isoforms and Receptors in Lesional Psoriatic Skin. Br J Dermatol (2009) 160(2):319–24. doi: 10.1111/j.1365-2133.2008.08902.x
66
BrembillaNCSenraLBoehnckeWH. The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond. Front Immunol (2018) 9:1682. doi: 10.3389/fimmu.2018.01682
67
FurueMFurueKTsujiGNakaharaT. Interleukin-17A and Keratinocytes in Psoriasis. Int J Mol Sci (2020) 21(4):1275. doi: 10.3390/ijms21041275
68
BoehnckeWH. Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences. Front Immunol (2018) 9:579. doi: 10.3389/fimmu.2018.00579
69
KirkhamBWKavanaughAReichK. Interleukin-17A: A Unique Pathway in Immune-Mediated Diseases: Psoriasis, Psoriatic Arthritis and Rheumatoid Arthritis. Immunology (2014) 141(2):133–42. doi: 10.1111/imm.12142
70
GriffithJWSokolCLLusterAD. Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity. Annu Rev Immunol (2014) 32:659–702. doi: 10.1146/annurev-immunol-032713-120145
71
OmenettiSBussiCMetidjiAIsepponALeeSTolainiMet al. The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells. Immunity (2019) 51(1):77–89.e6. doi: 10.1016/j.immuni.2019.05.004
72
MarksBRNowyhedHNChoiJYPoholekACOdegardJMFlavellRAet al. Thymic Self-Reactivity Selects Natural Interleukin 17-Producing T Cells That can Regulate Peripheral Inflammation. Nat Immunol (2009) 10(10):1125–32. doi: 10.1038/ni.1783
73
TeunissenMBMMunnekeJMBerninkJHSpulsPIResPCMTe VeldeAet al. Composition of Innate Lymphoid Cell Subsets in the Human Skin: Enrichment of NCR(+) ILC3 in Lesional Skin and Blood of Psoriasis Patients. J Invest Dermatol (2014) 134(9):2351–60. doi: 10.1038/jid.2014.146
74
Tait WojnoEDArtisD. Innate Lymphoid Cells: Balancing Immunity, Inflammation, and Tissue Repair in the Intestine. Cell Host Microbe (2012) 12(4):445–57. doi: 10.1016/j.chom.2012.10.003
75
ZhouLChongMMWLittmanDR. Plasticity of CD4+ T Cell Lineage Differentiation. Immunity (2009) 30(5):646–55. doi: 10.1016/j.immuni.2009.05.001
76
PrabhalaRHPelluruDFulcinitiMPrabhalaHKNanjappaPSongWet al. Elevated IL-17 Produced by TH17 Cells Promotes Myeloma Cell Growth and Inhibits Immune Function in Multiple Myeloma. Blood (2010) 115(26):5385–92. doi: 10.1182/blood-2009-10-246660
77
CaiYShenXDingCQiCLiKLiXet al. Pivotal Role of Dermal IL-17-Producing Gammadelta T Cells in Skin Inflammation. Immunity (2011) 35(4):596–610. doi: 10.1016/j.immuni.2011.08.001
78
Ness-SchwickerathKJMoritaCT. Regulation and Function of IL-17A- and IL-22-Producing Gammadelta T Cells. Cell Mol Life Sci (2011) 68(14):2371–90. doi: 10.1007/s00018-011-0700-z
79
BrembillaNCStalderRSenraLBoehnckeWH. IL-17A Localizes in the Exocytic Compartment of Mast Cells in Psoriatic Skin. Br J Dermatol (2017) 177(5):1458–60. doi: 10.1111/bjd.15358
80
CharitidisFTDamlundDSMKochJ. Psoriasis-Like Inflammation Induced in an Air-Pouch Mouse Model. In Vivo (2021) 35(4):1985–97. doi: 10.21873/invivo.12467
81
van der FitsLMouritsSVoermanJSKantMBoonLLamanJDet al. Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice is Mediated via the IL-23/IL-17 Axis. J Immunol (2009) 182(9):5836–45. doi: 10.4049/jimmunol.0802999
82
KuligPMusiolSFreibergerSNSchreinerBGyulvesziGRussoGet al. IL-12 Protects From Psoriasiform Skin Inflammation. Nat Commun (2016) 7:13466. doi: 10.1038/ncomms13466
83
HanselAGuntherCIngwersenJStarkeJSchmitzMBachmannMet al. Human Slan (6-Sulfo LacNAc) Dendritic Cells are Inflammatory Dermal Dendritic Cells in Psoriasis and Drive Strong TH17/TH1 T-Cell Responses. J Allergy Clin Immunol (2011) 127(3):787–94.e1-9. doi: 10.1016/j.jaci.2010.12.009
84
AricanOAralMSasmazSCiragilP. Serum Levels of TNF-Alpha, IFN-Gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in Patients With Active Psoriasis and Correlation With Disease Severity. Mediators Inflamm (2005) 2005(5):273–9. doi: 10.1155/MI.2005.273
85
ArmstrongAWVoylesSVArmstrongEJFullerENRutledgeJC. A Tale of Two Plaques: Convergent Mechanisms of T-Cell-Mediated Inflammation in Psoriasis and Atherosclerosis. Exp Dermatol (2011) 20(7):544–9. doi: 10.1111/j.1600-0625.2011.01308.x
86
AbdelnoorAMAl-AklN. Factors Involved in the Pathogenesis of Psoriasis. Adv Stud Med Sci (2013) 1(2):75–94. doi: 10.12988/asms.2013.13008
87
NumasakiMFukushiJOnoMNarulaSKZavodnyPJKudoTet al. Interleukin-17 Promotes Angiogenesis and Tumor Growth. Blood (2003) 101(7):2620–7. doi: 10.1182/blood-2002-05-1461
88
NumasakiMLotzeMTSasakiH. Interleukin-17 Augments Tumor Necrosis Factor-Alpha-Induced Elaboration of Proangiogenic Factors From Fibroblasts. Immunol Lett (2004) 93(1):39–43. doi: 10.1016/j.imlet.2004.01.014
89
YuXHJiangNZhengXLCayabyabFSTangZBTangCK. Interleukin-17A in Lipid Metabolism and Atherosclerosis. Clin Chim Acta (2014) 431:33–9. doi: 10.1016/j.cca.2014.01.012
90
QuFGaoHZhuSShiPZhangYLiuYet al. TRAF6-Dependent Act1 Phosphorylation by the IkappaB Kinase-Related Kinases Suppresses Interleukin-17-Induced NF-kappaB Activation. Mol Cell Biol (2012) 32(19):3925–37. doi: 10.1128/MCB.00268-12
91
TalebSTedguiAMallatZ. IL-17 and Th17 Cells in Atherosclerosis: Subtle and Contextual Roles. Arterioscler Thromb Vasc Biol (2015) 35(2):258–64. doi: 10.1161/ATVBAHA.114.303567
92
TalebSTedguiA. IL-17 in Atherosclerosis: The Good and the Bad. Cardiovasc Res (2018) 114(1):7–9. doi: 10.1093/cvr/cvx225
93
HirotaKDuarteJHVeldhoenMHornsbyELiYCuaDJet al. Fate Mapping of IL-17-Producing T Cells in Inflammatory Responses. Nat Immunol (2011) 12(3):255–63. doi: 10.1038/ni.1993
94
LeeYAwasthiAYosefNQuintanaFJXiaoSPetersAet al. Induction and Molecular Signature of Pathogenic TH17 Cells. Nat Immunol (2012) 13(10):991–9. doi: 10.1038/ni.2416
95
LiuZLuFPanHZhaoYWangSSunSet al. Correlation of Peripheral Th17 Cells and Th17-Associated Cytokines to the Severity of Carotid Artery Plaque and its Clinical Implication. Atherosclerosis (2012) 221(1):232–41. doi: 10.1016/j.atherosclerosis.2011.12.026
96
EidRERaoDAZhouJLoSFRanjbaranHGalloAet al. Interleukin-17 and Interferon-Gamma Are Produced Concomitantly by Human Coronary Artery-Infiltrating T Cells and Act Synergistically on Vascular Smooth Muscle Cells. Circulation (2009) 119(10):1424–32. doi: 10.1161/CIRCULATIONAHA.108.827618
97
MehtaNNTeagueHLSwindellWRBaumerYWardNLXingXet al. IFN-Gamma and TNF-Alpha Synergism may Provide a Link Between Psoriasis and Inflammatory Atherogenesis. Sci Rep (2017) 7(1):13831. doi: 10.1038/s41598-017-14365-1
98
AllamGAbdel-MoneimAGaberAM. The Pleiotropic Role of Interleukin-17 in Atherosclerosis. BioMed Pharmacother (2018) 106:1412–8. doi: 10.1016/j.biopha.2018.07.110
99
SherlockJPJoyce-ShaikhBTurnerSPChaoCCSatheMGreinJet al. IL-23 Induces Spondyloarthropathy by Acting on ROR-Gammat+ CD3+CD4-CD8- Entheseal Resident T Cells. Nat Med (2012) 18(7):1069–76. doi: 10.1038/nm.2817
100
GeremiaAArancibia-CarcamoCVFlemingMPRustNSinghBMortensenNJet al. IL-23-Responsive Innate Lymphoid Cells are Increased in Inflammatory Bowel Disease. J Exp Med (2011) 208(6):1127–33. doi: 10.1084/jem.20101712
101
WolfDLeyK. Immunity and Inflammation in Atherosclerosis. Circ Res (2019) 124(2):315–27. doi: 10.1161/CIRCRESAHA.118.313591
102
McGeachyMJBak-JensenKSChenYTatoCMBlumenscheinWMcClanahanTet al. TGF-β and IL-6 Drive the Production of IL-17 and IL-10 by T Cells and Restrain TH-17 Cell–Mediated Pathology. Nat Immunol (2007) 8(12):1390–7. doi: 10.1038/ni1539
103
BoechatJL. Psoriatic March, Skin Inflammation and Cardiovascular Events – Two Plaques for One Syndrome. Int J Cardiovasc Sci (2020) 33(2):109–11. doi: 10.36660/ijcs.20200021
104
FlammerAJRuschitzkaF. Psoriasis and Atherosclerosis: Two Plaques, One Syndrome? Eur Heart J (2012) 33(16):1989–91. doi: 10.1093/eurheartj/ehr425
105
GoldenJBMcCormickTSWardNL. IL-17 in Psoriasis: Implications for Therapy and Cardiovascular Co-Morbidities. Cytokine (2013) 62(2):195–201. doi: 10.1016/j.cyto.2013.03.013
106
MartinDATowneJEKricorianGKlekotkaPGudjonssonJEKruegerJGet al. The Emerging Role of IL-17 in the Pathogenesis of Psoriasis: Preclinical and Clinical Findings. J Invest Dermatol (2013) 133(1):17–26. doi: 10.1038/jid.2012.194
107
ZabaLCSuarez-FarinasMFuentes-DuculanJNogralesKEGuttman-YasskyECardinaleIet al. Effective Treatment of Psoriasis With Etanercept is Linked to Suppression of IL-17 Signaling, Not Immediate Response TNF Genes. J Allergy Clin Immunol (2009) 124(5):1022–10e1-395. doi: 10.1016/j.jaci.2009.08.046
108
McGeachyMJCuaDJGaffenSL. The IL-17 Family of Cytokines in Health and Disease. Immunity (2019) 50(4):892–906. doi: 10.1016/j.immuni.2019.03.021
109
ChiricozziAKruegerJG. IL-17 Targeted Therapies for Psoriasis. Expert Opin Investig Drugs (2013) 22(8):993–1005. doi: 10.1517/13543784.2013.806483
110
ChiricozziAGuttman-YasskyESuarez-FarinasMNogralesKETianSCardinaleIet al. Integrative Responses to IL-17 and TNF-Alpha in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in Psoriasis. J Invest Dermatol (2011) 131(3):677–87. doi: 10.1038/jid.2010.340
111
HanssonGKHermanssonA. The Immune System in Atherosclerosis. Nat Immunol (2011) 12(3):204–12. doi: 10.1038/ni.2001
112
BlauveltAChiricozziA. The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis. Clin Rev Allergy Immunol (2018) 55(3):379–90. doi: 10.1007/s12016-018-8702-3
113
RyuHChungY. Regulation of IL-17 in Atherosclerosis and Related Autoimmunity. Cytokine (2015) 74(2):219–27. doi: 10.1016/j.cyto.2015.03.009
114
AdamiSCavaniARossiFGirolomoniG. The Role of Interleukin-17A in Psoriatic Disease. BioDrugs (2014) 28(6):487–97. doi: 10.1007/s40259-014-0098-x
115
NashPKirkhamBOkadaMRahmanPCombeBBurmesterG-Ret al. Ixekizumab for the Treatment of Patients With Active Psoriatic Arthritis and an Inadequate Response to Tumour Necrosis Factor Inhibitors: Results From the 24-Week Randomised, Double-Blind, Placebo-Controlled Period of the SPIRIT-P2 Phase 3 Trial. Lancet (2017) 389(10086):2317–27. doi: 10.1016/s0140-6736(17)31429-0
116
DeodharAMeasePJMcInnesIBBaraliakosXReichKBlauveltAet al. Long-Term Safety of Secukinumab in Patients With Moderate-to-Severe Plaque Psoriasis, Psoriatic Arthritis, and Ankylosing Spondylitis: Integrated Pooled Clinical Trial and Post-Marketing Surveillance Data. Arthritis Res Ther (2019) 21(1):111. doi: 10.1186/s13075-019-1882-2
117
HawkesJEChanTCKruegerJG. Psoriasis Pathogenesis and the Development of Novel Targeted Immune Therapies. J Allergy Clin Immunol (2017) 140(3):645–53. doi: 10.1016/j.jaci.2017.07.004
118
LibbyP. Inflammation in Atherosclerosis. Arterioscler Thromb Vasc Biol (2012) 32(9):2045–51. doi: 10.1161/ATVBAHA.108.179705
119
WuMYLiCJHouMFChuPY. New Insights Into the Role of Inflammation in the Pathogenesis of Atherosclerosis. Int J Mol Sci (2017) 18(10):2034. doi: 10.3390/ijms18102034
120
HanssonGK. Inflammation, Atherosclerosis, and Coronary Artery Disease. N Engl J Med (2005) 352(16):1685–95. doi: 10.1056/NEJMra043430
121
HanssonGKLibbyPTabasI. Inflammation and Plaque Vulnerability. J Intern Med (2015) 278(5):483–93. doi: 10.1111/joim.12406
122
Silfvast-KaiserAPaekSYMenterA. Anti-IL17 Therapies for Psoriasis. Expert Opin Biol Ther (2019) 19(1):45–54. doi: 10.1080/14712598.2019.1555235
123
LibonFLebasEEl HayderiLDe SchaetzenVDezfoulianBNikkelsAF. Actual Treatments of Psoriasis : From Etanercept to Anti-IL17 and Anti-IL23 Antagonists. Rev Med Liege (2020) 75(5-6):376–81.
124
KarbachSCroxfordALOelzeMSchulerRMinwegenDWegnerJet al. Interleukin 17 Drives Vascular Inflammation, Endothelial Dysfunction, and Arterial Hypertension in Psoriasis-Like Skin Disease. Arterioscler Thromb Vasc Biol (2014) 34(12):2658–68. doi: 10.1161/ATVBAHA.114.304108
125
GelfandJMShinDBDuffinKCArmstrongAWBlauveltATyringSKet al. A Randomized Placebo-Controlled Trial of Secukinumab on Aortic Vascular Inflammation in Moderate-to-Severe Plaque Psoriasis (VIP-S). J Invest Dermatol (2020) 140(9):1784–93.e2. doi: 10.1016/j.jid.2020.01.025
126
LiYGoldenJBCamhiMIZhangXFritzYDiaconuDet al. Protection From Psoriasis-Related Thrombosis After Inhibition of IL-23 or IL-17a. J Invest Dermatol (2018) 138(2):310–5. doi: 10.1016/j.jid.2017.09.021
127
RoubilleCRicherVStarninoTMcCourtCMcFarlaneAFlemingPet al. The Effects of Tumour Necrosis Factor Inhibitors, Methotrexate, non-Steroidal Anti-Inflammatory Drugs and Corticosteroids on Cardiovascular Events in Rheumatoid Arthritis, Psoriasis and Psoriatic Arthritis: A Systematic Review and Meta-Analysis. Ann Rheum Dis (2015) 74(3):480–9. doi: 10.1136/annrheumdis-2014-206624
Summary
Keywords
interleukin (IL)-17, interleukin (IL)-17A, IL-23 / IL-17 axis, cardiovascular disease, atherosclerosis, psoriasis
Citation
Wang Y, Zang J, Liu C, Yan Z and Shi D (2022) Interleukin-17 Links Inflammatory Cross-Talks Between Comorbid Psoriasis and Atherosclerosis. Front. Immunol. 13:835671. doi: 10.3389/fimmu.2022.835671
Received
14 December 2021
Accepted
23 March 2022
Published
13 April 2022
Volume
13 - 2022
Edited by
Eva Reali, University of Milano-Bicocca, Italy
Reviewed by
Francesco Bellinato, University of Verona, Italy; Anna Lisa Giuliani, University of Ferrara, Italy
Updates
Copyright
© 2022 Wang, Zang, Liu, Yan and Shi.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Dongmei Shi, shidongmei28@163.com; Zhongrui Yan, zhongruiy@163.com
This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
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