CASE REPORT article

Front. Immunol.

Sec. Cancer Immunity and Immunotherapy

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1530363

Case Report: Sclerosing angiomatoid nodular transformation of the spleen : Surgery or Conservative Treatment?

Provisionally accepted
Shuai  YanShuai Yan1Zihan  WangZihan Wang1Jiajie  LuJiajie Lu1Liuxia  YuanLiuxia Yuan2Linling  JuLinling Ju2Huixuan  WangHuixuan Wang2Lin  ChenLin Chen2Weihua  CaiWeihua Cai3Feng  XiaoFeng Xiao4*Jinzhu  WuJinzhu Wu3*
  • 1School of Medicine, Nantong University, Nantong, China
  • 2Nantong Institute of Liver Diseases, Affiliated Nantong Hospital 3 of Nantong University, Nantong, Jiangsu Province, China
  • 3Department of Hepatobiliary Surgery, Affiliated Nantong Hospital 3 of Nantong University, Nantong, Jiangsu Province, China
  • 4Department of Pathology, Affiliated Nantong Hospital 3 of Nantong University, nantong, China

The final, formatted version of the article will be published soon.

Sclerosing angiomatoid nodular transformation (SANT)is a rare vascular sclerosing mass-like lesion, often discovered incidentally during routine imaging evaluation or during visits for the patient's primary disease. SANT has complex pathological manifestations, unknown natural course of development and rarity, which makes it difficult for clinicians and pathologists to define its true nature. We report a 55-year-old male patient who came to see a doctor due to a physical examination accidentally found a spleen mass. He had hypertension and hyperlipidemia, and had no obvious clinical symptoms. After that, he underwent surgical resection of the spleen, and the patient had no special discomfort after treatment. Our results show that surgical resection is an efficient treatment for SANT patients without obvious clinical symptoms, but the patient 's comprehensive conditions should also be considered.

Keywords: Sclerosing angiomatoid nodular transformation of the spleen, Sant, Spleen, case report, Cancer

Received: 18 Nov 2024; Accepted: 07 Jul 2025.

Copyright: © 2025 Yan, Wang, Lu, Yuan, Ju, Wang, Chen, Cai, Xiao and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Feng Xiao, Department of Pathology, Affiliated Nantong Hospital 3 of Nantong University, nantong, China
Jinzhu Wu, Department of Hepatobiliary Surgery, Affiliated Nantong Hospital 3 of Nantong University, Nantong, Jiangsu Province, China

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