REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1530407
Recent Advances in the Genetics and Innate Immune Cells of Bullous Pemphigoid
Provisionally accepted
- 1Department of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China
- 2Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China
- 3Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Bullous pemphigoid (BP) is a common autoimmune subepidermal blistering disease that primarily affects elderly patients. The pathogenesis of BP is complex, involving genetic, immune, and environmental factors. Recent evidence suggests that multiple genomic regions, particularly within the human leukocyte antigen (HLA)-II region, influence susceptibility to BP. Genetically predisposed individuals may carry susceptibility alleles that modulate the immune system, leading to an elevated risk of developing BP when exposed to the appropriate environmental triggers. Here, the present review discusses the genetics of BP and the critical role of the innate immune system in BP pathogenesis, focusing on the composition of innate immune cells.
Keywords: Bullous pemphigoid, Genetics, Genetic Susceptibility, innate immune cells, immune cells
Received: 18 Nov 2024; Accepted: 04 Jun 2025.
Copyright: © 2025 Yang, Wei and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zaixing Wang, Department of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.