ORIGINAL RESEARCH article
Front. Immunol.
Sec. Viral Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1532318
This article is part of the Research TopicViral Impact on CNS: Mechanisms of Immune Dysfunction and Cognitive DeclineView all 11 articles
IFIT3 Activation Significantly Contributes to HIV-1-Associated Neurodegenerative Disorder (HAND)-Mediated Neuroinflammation
Provisionally accepted
Ranjit Kumar Das1
Nirakar Sahoo1
Deepa Roy1Jose Galarza1Maria Camila1
Hansapani Rodrigo1
Chun Xu1
Asim K Duttaroy2
Upal Roy1*- 1The University of Texas Rio Grande Valley, Edinburg, Texas, United States
- 2University of Oslo, Oslo, Oslo, Norway
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The advent of effective combination antiretroviral therapy (cART) has significantly improved HIV-1 treatment, saving millions of lives. However, HIV-1-associated neurocognitive disorder (HAND) remains a concern, particularly among aging individuals with HIV-1. The mechanisms underlying HAND are not well understood. This study investigated the role of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and its upstream regulator, signal transducer, and activator of transcription 1 (STAT1), in HAND pathology. Using the SH-SY5Y neuroblastoma cell line and HIV-infected humanized mice, we examined the effects of the cART drugs, HIV Tat protein, and HIV-1 virus on STAT1 and IFIT3 expression. The results showed that HIV-1 exposure significantly upregulated STAT1 and IFIT3, contributing to neuroinflammation. This study identified IFIT3 as a critical molecular marker for HAND, suggesting its potential as a therapeutic target and offering new insights into disease pathology and treatment strategies.
Keywords: IFIT3, STAT1, CART, HIV, Tat protein, Hand, SH-SY5Y cells
Received: 21 Nov 2024; Accepted: 04 Jul 2025.
Copyright: © 2025 Das, Sahoo, Roy, Galarza, Camila, Rodrigo, Xu, Duttaroy and Roy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Upal Roy, The University of Texas Rio Grande Valley, Edinburg, Texas, United States
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