ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1536248
This article is part of the Research TopicCancer Cell Metabolism and Tumor Microenvironment RemodelView all articles
Aberrant Expression of PYGB as a Potential Therapeutic Target and Its Associations with Immune Cell Infiltration in Lung Cancer
Provisionally accepted
- 1Ganzhou Cancer Hospital, Ganzhou 341000, Jiangxi Province, China., Ganzhou, China
- 2Liuzhou People's Hospital, Liuzhou, Guangxi Zhuang Region, China
- 3Ganzhou People's Hospital, Ganzhou, Jiangxi Province, China
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Background: Brain glycogen phosphorylase (PYGB) facilitates the breakdown of glycogen, thereby supplying energy to tumor cells. While PYGB expression has been documented in various tumor types, its specific function in lung cancer (LC) remains to be elucidated. This study aims to explore the potential involvement of PYGB in the initiation and progression of LC.We systematically analyzed PYGB in LC using data from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) Cancer database, employing R and various online analytical tools. Elevated PYGB expression was observed in LC and was associated with poor clinical outcomes. In vitro experiments, immunohistochemistry (IHC) confirmed the aberrantly high expression of PYGB in LC. The application of PYGB-siRNA significantly inhibited the proliferation, migration, and invasion of LC cells. Further analysis demonstrated correlations between PYGB expression and immune infiltration, immune checkpoint expression, tumor mutation burden, and microsatellite instability in LC.This study unveils that elevated PYGB expression in LC is significantly correlated with poor prognosis, potentially attributable to PYGB's facilitation of LC cell proliferation, migration, and metastasis, as well as its significant association with the immune microenvironment.
Keywords: PYGB, LC, prognosis, Immune infiltration, biomarkers
Received: 28 Nov 2024; Accepted: 28 Apr 2025.
Copyright: © 2025 Sun, Xu, Qin and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kai Sun, Ganzhou Cancer Hospital, Ganzhou 341000, Jiangxi Province, China., Ganzhou, China
Fang-Fang Xie, Ganzhou People's Hospital, Ganzhou, Jiangxi Province, China
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