ORIGINAL RESEARCH article

Front. Immunol.

Sec. Comparative Immunology

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1539751

This article is part of the Research TopicCell-mediated innate immunity in aquatic invertebrates and fish: what’s new?View all 6 articles

Bioinformatics analyses of proteome of Holothuria tubulosa coelomic fluid and first evidence of primary cilium in coelomocyte cells

Provisionally accepted
Laura La PagliaLaura La Paglia1Manuela MauroManuela Mauro2Vincenzo ArizzaVincenzo Arizza2Alfonso UrsoAlfonso Urso1Simon SugárSimon Sugár3Drahos LaszloDrahos Laszlo3Vita Di StefanoVita Di Stefano2Claudio LuparelloClaudio Luparello2Mirella VazzanaMirella Vazzana2Aiti VizziniAiti Vizzini2*
  • 1National Research Council (CNR), Roma, Lazio, Italy
  • 2University of Palermo, Palermo, Italy
  • 3Research Centre for Natural Sciences, Hungarian Academy of Sciences (MTA), Budapest, Hungary

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In this work, we use the close phylogenetic relationship between H. tubulosa and vertebrates to study the evolution of immune genes. We propose a novel schematic model representing the putative interplay of immune-related proteins between extracellular and intracellular H. tubulosa in coelomic fluid (Fig. 8). In particular, in intracellular protein fraction, we identified an ancestral structure r ecalling vertebrate primary cilium, together with putative actin and cytoskeleton remodeling activated after pathogen sensing. This aims to cover knowledge gaps regarding mechanisms modulating specific immune cell phenotypes, behaviours, and functions highly conserved throughout evolution, involved in immune interactions with pathogens.

Keywords: Conceptualization, Data curation, Formal analysis, Funding acquisition, investigation, supervision, Writing -original draft, Writing -review & editing. Alfonso Urso: Funding acquisition

Received: 04 Dec 2024; Accepted: 07 Apr 2025.

Copyright: © 2025 La Paglia, Mauro, Arizza, Urso, Sugár, Laszlo, Di Stefano, Luparello, Vazzana and Vizzini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Aiti Vizzini, University of Palermo, Palermo, Italy

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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