BRIEF RESEARCH REPORT article

Front. Immunol.

Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1539830

This article is part of the Research TopicBiomarkers and Beyond: Predicting Course and Tailoring Treatment in Inflammatory Bowel DiseasesView all 4 articles

Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn's disease

Provisionally accepted
Dimitrios KioroglouDimitrios Kioroglou1Leire Egia-MendikuteLeire Egia-Mendikute1Asis PalazonAsis Palazon1Manuel Barreiro-de AcostaManuel Barreiro-de Acosta2Iago Rodríguez-LagoIago Rodríguez-Lago3*Urko M. MarigortaUrko M. Marigorta1*
  • 1CIC bioGUNE, Bilbao, Spain
  • 2Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Galicia, Spain
  • 3IIS Biobizkaia Institute, Barakaldo, Spain

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Despite the increasing incidence of Crohn’s disease (CD), its early immune disturbances have not all been described yet. We analysed single-cell RNASeq data from peripheral blood mononuclear cells of patients with incidentally-diagnosed CD, and compared their gene expression profile to healthy individuals. The main aim of our study was to perform an exploratory analysis of how the subclinical inflammatory process is modifying the individual’s immunologic environment while the patient is still in the preclinical period.

Keywords: Crohn's disease, scRNAseq, PBMC, preclinical, IBD

Received: 04 Dec 2024; Accepted: 28 Apr 2025.

Copyright: © 2025 Kioroglou, Egia-Mendikute, Palazon, Barreiro-de Acosta, Rodríguez-Lago and Marigorta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Iago Rodríguez-Lago, IIS Biobizkaia Institute, Barakaldo, 48903, Spain
Urko M. Marigorta, CIC bioGUNE, Bilbao, Spain

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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