SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Nutritional Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1547888
The effect of co-administration of vitamin E and C supplements on plasma oxidative stress biomarkers and antioxidant capacity: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials with meta-regression
Provisionally accepted
Mahdi Moabedi1*
Alireza Milajerdi2*- 1School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
- 2Research Center for Biochemistry and Nutrition in MetabolicDiseases, Kashan University of Medical Sciences, Kashan, Isfahan, Iran
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Background: There is no conclusion on the effect of vitamins E and C on plasma biomarkers of oxidative stress and antioxidant status. We conducted this meta-analysis to gain a clearer view of this area.We performed a systematic search in online databases using the relevant keyword combination. Randomized controlled trials that investigated the effect of vitamins E and C simultaneously, compared with control, on oxidative stress and antioxidant status biomarkers were included in the analyses.Results: A total of 17 trials were included in the meta-analysis, building a total sample size of 965.The dosage of vitamin E and C supplements varied from 54 to 536 and 250 to 1000 mg/d, respectively, across included studies. We found significant results for MDA [WMD: -0.38, 95%
Keywords: Oxidative Stress, Meta - analysis, Alpha tocoferol, randomized controlled trials, Antioxidant status, ascorbic acid
Received: 18 Dec 2024; Accepted: 27 Jun 2025.
Copyright: © 2025 Moabedi and Milajerdi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mahdi Moabedi, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
Alireza Milajerdi, Research Center for Biochemistry and Nutrition in MetabolicDiseases, Kashan University of Medical Sciences, Kashan, 87137.81147, Isfahan, Iran
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