ORIGINAL RESEARCH article
Front. Immunol.
Sec. Mucosal Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1551892
This article is part of the Research TopicNatural Products and Intestinal Mucosal ImmunityView all 10 articles
Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization
Provisionally accepted
- 1The Fifth People's Hospital of Jinan City, Jinan, Shandong Province, China
- 2Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
- 3Jining Medical University, Jining, Shandong, China
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Ulcerative colitis (UC)-related lung injurys is a commonly overlooked extraintestinal manifestation and there are currently no drugs with definitive efficacy available.Cimifugin has been found to inhibit aberrant inflammation and oxidative stress, but its efficacy in UC-related lung injurys has not yet been demonstrated. This study explored the effects of Cimifugin on UC-related lung injurys using RNA-seq in combination with 16S rRNA sequencing. The results showed that cimifugin significantly ameliorated symptoms and attenuated colon and lung injury in a UC mouse model, restored the integrity of the intestinal and lung epithelial barriers, and suppressed lung inflammation, which was achieved by inhibiting the JAK1/STAT1 pathway and the M1 macrophage-mediated inflammatory state in the colon and lungs, as well as by improving the homeostasis of the intestinal microbiota. In conclusion, our study provides new insights into the immune landscape and drug development for UC-related lung injurys.
Keywords: Cimifugin, ulcerative colitis-related lung injurys, JAK1/STAT1, Gut Microbiota, macrophage
Received: 26 Dec 2024; Accepted: 11 Jun 2025.
Copyright: © 2025 Wang, Yang, Zang, Shen, Huang, ma and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fan Yang, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, Shandong Province, China
Ming Li, Jining Medical University, Jining, 272067, Shandong, China
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