REVIEW article
Front. Immunol.
Sec. Microbial Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1553013
This article is part of the Research TopicModulation of Pulmonary Immunity and Function by Bacterial and Host MetabolitesView all 5 articles
Pseudomonas aeruginosa-Derived Metabolites and Volatile Organic Compounds: Impact on Lung Epithelial Homeostasis and Mucosal Immune Response
Provisionally accepted
- University of Illinois at Urbana-Champaign, Champaign, United States
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Pulmonary diseases, such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and ventilator-associated pneumonia (VAP), are attributed to the prolonged infection of the airway and hypersecretion of mucus. Pseudomonas aeruginosa (PA) is one of the most common nosocomial pathogens in these diseased airways, secreting a wide spectrum of metabolites and volatile organic compounds (VOCs) that significantly impact the respiratory epithelium, including disruption of mucus homeostasis and inflammatory responses of the diseased lungs. In this review, we highlighted the major metabolites and VOCs produced by PA and the mechanisms by which they modulate inflammation, cellular injury, and mucus hypersecretion in respiratory epithelium.
Keywords: Pseudomonas aeruginosa, Volatile Organic Compounds, bacterial metabolites, airway mucus dysregulation, Pulmonary immunity
Received: 29 Dec 2024; Accepted: 22 May 2025.
Copyright: © 2025 Kuo and Lau. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gee W Lau, University of Illinois at Urbana-Champaign, Champaign, United States
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