REVIEW article

Front. Immunol.

Sec. Inflammation

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1557250

This article is part of the Research TopicImmunity, Atherosclerosis and Cardiovascular Disease: An Interdisciplinary Approach to Cardiometabolic HealthView all 17 articles

cardiac lymphatics immune cell myocardial infarction Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction

Provisionally accepted
  • 1Department of Cardiovascular Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • 2Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • 3First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, China

The final, formatted version of the article will be published soon.

Myocardial infarction (MI) is a life-threatening disease with high morbidity and mortality, closely associated with immune-inflammatory responses. As essential pathways for immune cell clearance and interstitial fluid drainage, lymphatic vessels are critical in regulating tissue fluid homeostasis and systemic immune surveillance. Cardiac lymphatics interact with immune cells, directly and indirectly, to mediate post-MI inflammation, participate in the clearance of necrotic tissue, and contribute to cardiac remodeling. Studies indicate that after MI, promoting cardiac lymphangiogenesis can accelerate the clearance of infiltrated immune cells, reduce the production of pro-inflammatory cytokines, improve myocardial edema, mitigate inflammatory responses and fibrosis, and support recovery of cardiac function.Meanwhile, immune cells regulate the structure and function of cardiac lymphatics, cardiac lymphatics immune cell myocardial infarction influencing lymphangiogenesis and drainage efficiency. The interaction between cardiac lymphatics and immune cells is crucial for myocardial repair post-MI. This review first systematically summarizes the structure and function of cardiac lymphatics, then sorting the relationship between cardiac lymphatics and immune cells and their roles in myocardial repair after MI, and finally proposes therapeutic strategies targeting the interaction between cardiac lymphatics and immune cells in MI treatment, to provide prospective insights for the prevention and treatment of MI in the future.

Keywords: AMI, Acute Myocardial Infarction, WHO, World Health Organization, LEC, lymphatic endothelial cells, PDPN, podoplanin, PROX1, Prospero homeobox1, LYVE-1, lymphatic vessel endothelial receptor-1, LSMCs, lymphatic smooth muscle cells, αSMA, α-smooth muscle actin

Received: 08 Jan 2025; Accepted: 29 Apr 2025.

Copyright: © 2025 Yang, Zhang, Feng, Ning, Guo, Du, Wang, Wang and Mao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Xianliang Wang, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, China
Jingyuan Mao, Department of Cardiovascular Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China

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