REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1558488
This article is part of the Research TopicAdvancements in Immune Heterogeneity in Inflammatory Diseases and Cancer: New Targets, Mechanisms, and StrategiesView all 17 articles
The distinct biological role of JAML positions it as a promising target for treating human cancers and a range of other diseases
Provisionally accepted
- Jinan Central Hospital, Jinan, China
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Junctional adhesion molecule-like protein (JAML), a member of the junctional adhesion molecule (JAM) family, is widely expressed in various cells. This review examines the progress made in understanding JAML, beginning with its discovery and subsequent characterization. It emphasizes the mechanisms through which JAML influences biological processes, including cell migration, inflammation, lipid metabolism, and antitumor immunity, as demonstrated by recent studies. In addition, the clinical relevance of JAML is analyzed in the context of diseases linked to these processes. Particular attention is given to the effects of JAML on tumor cell proliferation and migration, alongside its pivotal role in regulating lymphocyte infiltration into the tumor microenvironment. Collectively, The balance between JAML's pro-inflammatory and anti-tumor functions underscores its therapeutic promise.
Keywords: cancer immunotherapy1, Junctional adhesion molecule-like protein (JAML)2, lipid metabolism3, T-cell infiltration4, Inflammatory response5
Received: 10 Jan 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Dong, Sun and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Meili Sun, Jinan Central Hospital, Jinan, China
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