ORIGINAL RESEARCH article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1559360
This article is part of the Research TopicCommunity Series in Towards Precision Medicine for Immune-Mediated Disorders: Advances in Using Big Data and Artificial Intelligence to Understand Heterogeneity in Inflammatory Responses, Volume IIIView all 3 articles
A bibliometric analysis of macrophage-associated immune regulation in atherosclerosis: advances in the mechanisms of pathogenesis
Provisionally accepted
- 1Kunming Medical University, Kunming, China
- 2The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
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The occurrence and development of atherosclerosis (AS) is closely related to immune regulation. Macrophages serve as the primary immune cells involved in AS. However, the mechanisms underlying macrophage-mediated immune regulation in AS remain inadequately understood, necessitating the development of novel immunotherapeutic strategies. This article aims to review the current status and emerging trends in macrophage immune regulation related to AS on a global scale.We utilized the Web of Science Core Collection database to identify articles pertaining to macrophage immune regulation in AS published between 2000 and 2024.Bibliometric methods were used to analyze authors, institutions, countries, journals and references through CiteSpace and VOSviewer. A total of 801 articles were included in this study.The United States has published the highest number of articles in this field, followed closely by China. Maastricht University stands out as a leading institution specializing in macrophage immune regulation related to AS. Esther Lutgens from Germany has made significant contributions to this area of research. The authors identified "Arteriosclerosis, Thrombosis, and Vascular Biology" as the most influential journal within this domain. Through cluster analysis, the keywords were categorized into four primary groups: (1) autoantibodies, (2) activation, (3) immune activation, and (4) nuclear receptors.This study systematically summarizes the findings of macrophage immune regulation research in AS from 2000 to 2024, while also describing and predicting global research hotspots and trends. The investigation into the molecular mechanisms underlying macrophage immune regulation in AS is poised to become a prominent topic in future studies.
Keywords: bibliometric analysis, Atherosclerosis, Macrophages, mechanisms, Immune Regulation
Received: 12 Jan 2025; Accepted: 26 May 2025.
Copyright: © 2025 Jiang, Han, Li and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guofu Zhu, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650031, Yunnan Province, China
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