ORIGINAL RESEARCH article
Front. Immunol.
Sec. Immunological Tolerance and Regulation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1561650
This article is part of the Research TopicAllergic Diseases Through Precision MedicineView all 4 articles
Expression and Correlation of SOCS3 and Eotaxin mRNA and Proteins and Their mRNA Levels in Nasal Mucosal Tissue of Allergic Rhinitis Patients
Provisionally accepted
- Renmin Hospital, Hubei University of Medicine, Shiyan, China
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Objective: This study aims to investigate the expression and interaction mechanisms of Suppressor of Cytokine Signaling 3 (SOCS3) and Eotaxin in the nasal mucosal tissues of patients with Allergic Rhinitis (AR).Methods: In this retrospective study, we selected nasal mucosa tissues from 35 AR patients as the AR group, and nasal mucosa tissues from 22 patients with isolated nasal septum deviation as the control group. Utilizing reverse transcription polymerase chain reaction (RT-PCR) techniques, we measured the expression levels of SOCS3 mRNA and Eotaxin mRNA in both groups. Additionally, immunohistochemical methods were employed to assess the protein expression of SOCS3 and Eotaxin in these tissues.Results: The average optical density value of SOCS3 protein in the AR group was 0.270±0.05, significantly higher than 0.160±0.04 in the control group (P<0.01); the average optical density value of Eotaxin protein in the AR group was 0.240±0.04, also significantly higher than 0.164±0.03 in the control group (P<0.01). At the mRNA level, the ratio of SOCS3 mRNA to GAPDH in the AR group was 0.83±0.27, and the ratio of Eotaxin mRNA to GAPDH was 0.71±0.21, both significantly higher than 0.32±0.11 and 0.22±0.08 in the control group. Besides, the expression levels of SOCS3 protein and mRNA in the nasal mucosal tissues of AR patients were positively correlated with the expression of Eotaxin protein and mRNA (r=0.927, P<0.01; r=0.854, P<0.01).Conclusion: The high expression of SOCS3 and Eotaxin in the nasal mucosal tissues of AR, as well as the positive correlation between them, suggest that they may play an important role in the pathogenesis of AR. This study provides new experimental evidence for in-depth understanding of the pathogenesis of AR and new potential targets for the treatment of AR.
Keywords: Suppressor of cytokine signaling 3, eosinophil, eosinophil chemotactic factor, allergic rhinitis, Expression
Received: 16 Jan 2025; Accepted: 09 May 2025.
Copyright: © 2025 Kang, Xu, Ai, Qu, Li and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lixin Wang, Renmin Hospital, Hubei University of Medicine, Shiyan, China
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