SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1563108
This article is part of the Research TopicFerroptosis and regulation mechanism in the tumor immune microenvironment for tumor progression and treatmentView all 6 articles
Emerging research themes in ferroptosis research for non-small cell lung cancer : a bibliometric and visualized analysis
Provisionally accepted- 1Gansu University of Chinese Medicine, Lanzhou, Gansu, China
- 2Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China
- 3First Hospital of Lanzhou University, Lanzhou, Gansu Province, China
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Ferroptosis, an iron-dependent form of regulated cell death, has garnered significant attention as a potential therapeutic target in oncology due to its unique mechanism involving lipid peroxidation and reactive oxygen species accumulation. In non-small cell lung cancer (NSCLC), ferroptosis offers promising strategies to overcome drug resistance and enhance the efficacy of existing therapies. While the literature on ferroptosis in NSCLC has expanded rapidly over the past decade, a comprehensive understanding of its research trends, global collaboration patterns, and emerging hotspots remains lacking.This study employs bibliometric and visualized analysis to systematically evaluate global research trends, influential contributors, and thematic evolution in ferroptosis research for NSCLC. The findings aim to guide future investigations and promote interdisciplinary collaborations.Data were extracted from the Web of Science Core Collection on December 24, 2024. Bibliometric tools including VOSviewer, CiteSpace, and GraphPad Prism were used to analyze publication trends, citation patterns, collaborative networks, and research hotspots. Key indicators such as publication output, geographic contributions, institutional performance, and keyword co-occurrence were visualized to elucidate the field's development. Results A total of 964 publications from 52 countries and regions were analyzed, with China and the United States emerging as the most influential contributors. Chinese institutions such as Fudan University and Central South University led in publication output, while US-based authors had the highest citation impact. Research hotspots included ferroptosis mechanisms, biomarkers, oxidative stress, immunotherapy, and drug resistance. Keyword and citation analyses reveal an increasing emphasis on integrating ferroptosis inducers with immune checkpoint inhibitors and leveraging nanomedicine for targeted therapy.This bibliometric analysis highlights the rapid expansion of ferroptosis research in NSCLC, revealing key contributors, global trends, and emerging areas of focus. The integration of ferroptosis with immunotherapy and precision medicine holds immense promise for advancing NSCLC treatment. Future research should prioritize international collaboration, explore resistance mechanisms, and harness advanced technologies such as nanomedicine and artificial intelligence to maximize therapeutic potential.
Keywords: ferroptosis, Non-small cell lung cancer, Bibliometrics, Immunotherapy, biomarkers, Drug Resistance, Nanomedicine
Received: 19 Jan 2025; Accepted: 28 Apr 2025.
Copyright: © 2025 Zhang, Gu, Chen, Jiang, Gonzalez-Rivas, Ma and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Minjie Ma, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China
Chang Chen, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu, China
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