REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1567040
This article is part of the Research TopicCommunity Series in Notch Signaling as a Regulator of Tumor Immune Response: Volume IIView all articles
The Role of Notch Signaling Pathway and Non-Coding RNAs in Cancer and Inflammation: Progress, Therapeutic Insights, and Future Directions
Provisionally accepted
- Zhengzhou University of Light Industry, Zhengzhou, China
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The Notch signaling pathway and non-coding RNAs (ncRNAs) play significant roles in regulating key cellular processes such as cancer progression, metastasis, and drug resistance. This article systematically reviews the interactions between the Notch pathway and ncRNAs including miRNAs, lncRNAs, and circRNAs, as well as their overall impact on cancer biology. We focus on the latest research progress on how ncRNAs regulate the Notch pathway through transcriptional regulation, post-transcriptional modifications, and epigenetic mechanisms, and discuss how such interactions affect tumor microenvironment shaping, immune escape mechanisms, and treatment sensitivity. Additionally, this article deeply analyzes potential therapeutic strategies targeting the Notch-ncRNA axis, including its prospects for synergistic application with chemotherapy, radiotherapy, and immunotherapy. By integrating multi-cancer experimental data, we propose individualized diagnosis and treatment strategies based on tumor-specific Notch pathway and ncRNA expression patterns.
Keywords: Notch signaling pathway1, precision medicine2, cancer treatment3, immunotherapy 4, Targeted therapy 5
Received: 26 Jan 2025; Accepted: 27 May 2025.
Copyright: © 2025 Zu, Hang, Shuang, Chen, Min, Kun, Hui and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li Pei Feng, Zhengzhou University of Light Industry, Zhengzhou, China
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