REVIEW article

Front. Immunol.

Sec. Cancer Immunity and Immunotherapy

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1567524

This article is part of the Research TopicCommunity Series in Notch Signaling as a Regulator of Tumor Immune Response: Volume IIView all articles

The Role of Notch Signaling Pathway in Cancer: Mechanistic Insights, Therapeutic Potential, and Clinical Progress

Provisionally accepted
  • Zhengzhou University of Light Industry, Zhengzhou, China

The final, formatted version of the article will be published soon.

This article presents a comprehensive literature review on the role of the Notch signaling pathway in cancer and its molecular mechanisms. The Notch signaling pathway plays an important role in various types of cancer by regulating key biological processes such as epithelial-endothelial transition, angiogenesis, apoptosis and metabolic reprogramming. This article reviews the relevant mechanisms of the Notch signaling pathway in colorectal cancer, ovarian cancer, oral squamous cell carcinoma, gastric cancer and chronic lymphocytic leukemia, highlighting its dual roles in promoting tumor growth, inhibiting tumor progression and potential therapeutic applications in oncology. Meanwhile, the key roles of the Notch signaling pathway in regulating tumor drug resistance and shaping the tumor microenvironment are discussed, highlighting its importance in clinical applications. Through this review, some ideas and hints for future research directions can be provided to the readers of Notch pathway related research.

Keywords: Notch signaling pathway1, Cancer2, Tumor development3, therapeutic potential4, Clinical progress5

Received: 27 Jan 2025; Accepted: 27 May 2025.

Copyright: © 2025 Zhang, Hang, Jing, Liu, Li, 王, Luo, Lv, Tao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Peifeng Li, Zhengzhou University of Light Industry, Zhengzhou, China

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