ORIGINAL RESEARCH article
Front. Immunol.
Sec. NK and Innate Lymphoid Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1568875
This article is part of the Research TopicUncovering the Immune Context of Lymphoproliferative DiseasesView all articles
Innate Lymphoid Cells in Bone Marrow and Blood of Healthy and Myelodysplastic Patients
Provisionally accepted
- 1Hospital Israelita Abert Einstein, Sao Paulo, Brazil
- 2Albert Einstein Israelite Hospital, São Paulo, Brazil
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Currently, subsets of lymphocytes have been identified as innate lymphoid cells (ILC). These cells are known to play effector and regulatory roles and have been divided into three subtypes, ILC1, ILC2 and ILC3 based on their specific characteristics and secretome. The bone marrow (BM) microenvironment in Myelodysplastic Neoplasms (MDS) is affected by increased levels of cytokines and inflammatory responses. In this study, we aimed to determine the frequency and number of ILC in BM and peripheral blood (PB) of healthy individuals (HI) and compare them to MDS-BM. ILC1 was present in all PB and BM samples. However, ILC2 and ILC3, were identified in all BM and PB samples from healthy individuals, but were mostly absent in MDS-BM. This study also demonstrates a potential maturation curve for BM-ILC evaluation. Our data indicates that there is a discrepancy in the ILC maturation curve in the MDS-BM when compared to HI-BM.
Keywords: innate lymphocytes, Myelodysplastic neoplasms, Flow Cytometry, ILC2 - group 2 innate lymphoid cell, ILC1 -group 1 innate lympocyte, ILC3 -group 3 innate lympocyte
Received: 30 Jan 2025; Accepted: 19 May 2025.
Copyright: © 2025 Bento, Cebineeli, Bacal and Marti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Luciana Cavalheiro Marti, Albert Einstein Israelite Hospital, São Paulo, Brazil
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