CASE REPORT article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1569011
This article is part of the Research TopicImmunological Aspects and Immunotherapy in Gynecologic CancersView all 12 articles
A case report of small cell neuroendocrine carcinoma of the ovary and review of the literature
Provisionally accepted
- Department of Obstetrics and Gynecology, the Second Afliated Hospital of Dalian Medical University, No. 467, Zhongshan Road, Shahekou District, Dalian 116023, Liaoning, People’s Republic of China, Dalian, China
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Small cell neuroendocrine carcinoma of the ovary is rare pathological type with an undefined mechanism, low incidence, but high metastatic rate, high aggressiveness, and very poor prognosis, and there are no standardized treatment protocols or guidelines. In this article, we report a 48-year-old woman diagnosed with small cell neuroendocrine carcinoma of the ovary after puncture biopsy of a pelvic mass, who underwent 8 cycles of paclitaxel+carboplatin regimen chemotherapy (with the addition of the anti-angiogenesis targeted agent bevacizumab in the first 2 times, and the immunosuppressant tirilizumab in the last 2 times), followed by 12 times of tirilizumab monotherapy maintenance therapy, which was highly effective. It is believed that with newer technologies, the use of surgery, chemotherapy combined with immunotherapy, targeted therapy, genetic testing and construction of animal tumor models will play a key role in the treatment and monitoring of the prognosis of this rare disease.
Keywords: Small cell neuroendocrine carcinoma, chemotherapy, Immunotherapy, targeted therapy, malignant tumor of ovary
Received: 31 Jan 2025; Accepted: 29 Apr 2025.
Copyright: © 2025 Zhao, Kang, Kong and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ning Wang, Department of Obstetrics and Gynecology, the Second Afliated Hospital of Dalian Medical University, No. 467, Zhongshan Road, Shahekou District, Dalian 116023, Liaoning, People’s Republic of China, Dalian, China
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