REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1571573
Immune characteristics of olfactory ensheathing cells and repair of nerve injury
Provisionally accepted
- Nanchang University, Nanchang, China
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The process of nerve injury is accompanied by the change of inflammatory microenvironment, which is not conducive to axonal regeneration and hinders the repair of injured nerve. Therefore, looking for a way to improve the inflammatory attack and immune state around the injured nerve is beneficial to the progress of nerve injury repair. In recent years, cell transplantation strategy has played a foreground role in the repair of nerve injury. Olfactory ensheathing cells (OECs) are a special kind of glial cells, which have the characteristics of continuous renewal and survival, antigenic characteristics, variability and promoting the repair of nerve injury. OECs have been recognized in different injury models, including clinical trials, which has become a dominant cell in cell replacement therapy. An important feature of OECs lies in their anti-inflammatory and immunomodulatory functions. They are transplanted into the host to improve the catastrophic inflammatory microenvironment caused by injured nerves, thus promoting the repair and regeneration of injured nerves. The transplantation of OECs into the host can provide good groundwork and support for the repair and regeneration of nerve injury by regulating the activity and infiltration of immune cells, the secretion of inflammatory cytokines and phagocytosis. Therefore, this paper discusses the anti-inflammatory and immunomodulatory mechanisms of OECs transplantation in the repair of nerve injury and the functional role of OECs as an ideal substitute in the treatment of nerve injury.
Keywords: OECS, Immune Regulation, anti-inflammation, nerve injury repair, Regeneration
Received: 05 Feb 2025; Accepted: 25 Apr 2025.
Copyright: © 2025 Zhang, Zuo and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wen-jun Zhang, Nanchang University, Nanchang, China
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