BRIEF RESEARCH REPORT article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1571585
This article is part of the Research TopicApproaches to Illustrate the Tumor Immune MicroenvironmentView all 10 articles
Immunohistochemical expression of IL-1β, IL-6, and NF-κβ in fibroids
Provisionally accepted
Mateusz de Mezer1*
Natalia Dolata1
Janina Markowska2Monika Krzyżaniak3Agnieszka Naskręt-Grochowalska4Jakub Żurawski1Anna Markowska5- 1Department of Immunobiology, Poznan University of Medical Sciences,, Poznan, Poland
- 2Gynecological Center, Poznan, Poland
- 3Department of Oncological Pathology, Lord’s Transfiguration Clinical Hospital, Partner of Poznan University of Medical Sciences,, Poznan, Poland
- 4SPZOZ in Gostyń, Gostyn, Poland
- 5Department of Perinatology and Women’s Diseases, Poznan University of Medical Sciences, Poznan, Poland
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Uterine fibroids are benign tumors that occur in a large proportion of women and interfere with the proper functioning of this organ. One of the factors leading to these proliferative changes appears to be the appearance of extracellular matrix (ECM) fibrosis at the site of local inflammatory foci. Due to the potential impact of cytokines in this process, it is interesting to determine their expression levels in fibroids and surrounding tissues, which may contribute to a better understanding of the mechanisms leading to the formation of these tumors.In tissue material from 50 women with uterine fibroids who underwent hysterectomy and 45 women operated on for other reasons (most often prolapse of the reproductive organ), the concentration of inflammatory cytokines IL-1β and IL-6 and the concentration of the transcription nuclear factor NFκβ were determined. The tissue from the fibroid, the peripheral myometrium, and the unchanged myometrium were examined in women who underwent surgery for reasons other than uterine fibroids.A significant decrease in IL-1β levels was observed in the center of the fibroid compared to both 2 peripheral and control muscle tissue (p=0.001). The concentrations of IL-6 were found to be similar across all three locations examined. The NF-κβ levels were significantly lower in the fibroid and peripheral tissues (p<0.001) compared to the control group. The concentration of IL-1β was found to be significantly and positively correlated with the concentration of NF-κβ in uterine fibroids.
Keywords: Uterine fibroids, IL-1β (Interleukin-1 beta), IL-6 (Interleukin 6), Nf-κβ, Myoma
Received: 05 Feb 2025; Accepted: 10 Jun 2025.
Copyright: © 2025 de Mezer, Dolata, Markowska, Krzyżaniak, Naskręt-Grochowalska, Żurawski and Markowska. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mateusz de Mezer, Department of Immunobiology, Poznan University of Medical Sciences,, Poznan, Poland
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