MINI REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1573174
This article is part of the Research TopicSentinels of the Immune System: Tissue-Resident Macrophages in the Battle Against Infection and AutoimmunityView all 3 articles
Role of Macrophages in Neuroimmune Regulation
Provisionally accepted
- Huazhong University of Science and Technology, Wuhan, China
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Macrophages, as essential components of the immune system, play pivotal roles in regulating neuroimmune interactions. These cells exist in two primary forms: tissue-resident macrophages and monocyte-derived macrophages (MDMs), each exhibiting distinct functions in neuroimmune responses. Tissue-resident macrophages maintain tissue homeostasis and act as the first line of defense against pathogens, while MDMs are recruited during inflammation, performing both phagocytic and immunomodulatory functions. Despite the recognized roles of these macrophage populations in systemic immunity, their specific contributions to neuroimmune regulation remain poorly understood. This review aims to elucidate the differential roles of tissue-resident macrophages and MDMs in the neuroimmune pathway. We explore their mechanisms of activation, interaction with other immune cells, and involvement in inflammatory processes within the central nervous system (CNS). By identifying the distinct and overlapping functions of these macrophage populations, this review may provide novel insights into therapeutic strategies aimed at modulating neuroimmune responses, particularly in the context of neuroinflammatory disorders such as neurodegenerative diseases.
Keywords: Macrophages, neuroimmune, MDM, CNS, tissue-resident macrophages
Received: 08 Feb 2025; Accepted: 03 Jun 2025.
Copyright: © 2025 Xiao and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kai Yang, Huazhong University of Science and Technology, Wuhan, China
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