SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1574736
Tracing the history of clinical practice of liquid biopsy: a bibliometric analysis
Provisionally accepted
- 1College of New Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- 2Department of Third Cardre’s Ward, General Hospital of Northern Theater Command, Shenyang, China
- 3School of Medicine, Southeast University, Nanjing, China
- 4Department of Ultrasound, Liaocheng People's Hospital, Liaocheng, China
- 5Department of Organ Transplantation and Hepatobiliary Surgery, The first hospital of China Medical University, Shenyang, China
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Liquid biopsy holds great promise in clinical diagnosis, treatment, and prognostic monitoring. This study reveals the development of liquid biopsy in clinical practice through a comprehensive bibliometric analysis. A total of 40 years of research literature in this field was included from the Web of Science Core Collection (WoSCC), analyzing the evolving research trends of liquid biopsy in clinical practice. We constructed co-occurrence networks for countries, institutions, authors, and keywords, integrating citation analysis and journal impact metrics to provide a comprehensive view of the research landscape in the field of liquid biopsy. The results show a significant growth trend in the clinical practice of liquid biopsy, with China and the United States being the leading contributors. Institutions such as Harvard University and the University of California system play a central role in the global collaboration network. Cancers has become the primary publication outlet for the field, while highly cited journals like Clinical Cancer Research play a crucial role in advancing its development. Keyword analysis reveals that research has progressively expanded into clinical applications, personalized treatment, and prognostic evaluation. Overall, as technology and applications continue to mature, liquid biopsy is expected to play an even greater role in the early diagnosis, treatment evaluation, and personalized treatment of cancer and other diseases.
Keywords: liquid biopsy, clinical practice, biomarkers, bibliometric analysis, Cancer
Received: 11 Feb 2025; Accepted: 23 Apr 2025.
Copyright: © 2025 Zhang, Zhao, Wang, Li, Qi, Lu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Pan Qi, Department of Organ Transplantation and Hepatobiliary Surgery, The first hospital of China Medical University, Shenyang, China
Meitong Lu, Department of Third Cardre’s Ward, General Hospital of Northern Theater Command, Shenyang, China
Xing Zhang, Department of Third Cardre’s Ward, General Hospital of Northern Theater Command, Shenyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.