ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1575497
Prognostic significance of systemic immunoinflammatory biomarkers in patients with clear cell renal cell carcinoma: a retrospective multicenter analysis
Provisionally accepted
- The First People’s Hospital of Yunnan Province, Kunming, China
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Aims This study aims to investigate the associations between blood laboratory findings, systemic immune-inflammatory factors, ISUP grade, and prognostic outcomes in patients diagnosed with clear cell renal cell carcinoma (ccRCC). Methods Data were collected from patients diagnosed with ccRCC at the First People's Hospital of Yunnan Province and Xiangya Hospital of Central South University between 2010 and 2022, encompassing pertinent pathological and clinical information. We employed ordered logistic regression analysis to establish the ISUP grading model and conducted association analyses to explore the relationship between ISUP classification and the 2-year survival rate. Results A total of 1,635 patients were included in the study. Our findings indicate that ISUP grading is significantly correlated with serum albumin levels, blood chloride concentrations, the platelet-to-lymphocyte ratio (PLR), and the systemic inflammation response index (SIRI). The preoperative 2-year survival model demonstrated associations with platelet counts (PLT), albumin levels, blood chloride concentrations, and PLR, AUC (0.776 95%IC 0.710, 0.843). Furthermore, the postoperative 2-year survival model exhibited robust correlations with PLT, albumin levels, blood chloride concentrations, PLR, and ISUP grade, AUC (0.877, 95%IC 0.825, 0.917). Conclusion This study demonstrated the relationship between systemic immune markers, ISUP classification, and prognosis. It established preoperative models for predicting ISUP classification, as well as models for predicting 2-year survival rates both preoperatively and postoperatively.
Keywords: ccRCC, ISUP, NLR, PLR, LMR, SII, SIRI
Received: 12 Feb 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Chen, Zhang, Dong, Feng and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Junfeng Yang, The First People’s Hospital of Yunnan Province, Kunming, China
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