PERSPECTIVE article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1578486
This article is part of the Research TopicUnraveling Radiation Therapy's Role in Tumor Immunology and Systemic Antitumor ResponsesView all articles
Stereotactic Body Radiation Therapy or Conventional Fractionated Radiotherapy Combined with Immune Checkpoint Inhibitors? From Biological Perspectives
Provisionally accepted
- Taizhou Central Hospital, Taizhou, China
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We concentrated on a paper, “Radiation With Immunotherapy May Be a Double-Edged Sword—How Can We Learn From Recent Negative Clinical Trials?” published in JAMA Oncology recently. Herein, we initially provided three complemental viewpoints from biological perspectives involved in the dynamic alterations of the tumor microenvironment, which may contribute to a more comprehensive understanding of the SBRT’s superiority.
Keywords: SBRT, Tumor Microenvironment, radiosensitivity, Immunotherapy, immune checkpoint inhibitors
Received: 17 Feb 2025; Accepted: 11 Jul 2025.
Copyright: © 2025 Liu, Ye, Chen, Ding, Ying and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shenpeng Ying, Taizhou Central Hospital, Taizhou, China
Shixiu Wu, Taizhou Central Hospital, Taizhou, China
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