Introduction
We read with interest the article entitled “Positive correlation between different triglyceride glucose index-related indices and psoriasis: evidence from NHANES” by Huang et al. (1). This study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 2003 to 2006 and 2009 to 2014, focusing on adults aged 20 to 80 years. It innovatively explored the relationship between psoriasis and triglyceride glucose–body mass index (TyG-BMI), triglyceride glucose–waist to height ratio (TyG-WHtR), and triglyceride glucose–waist circumference (TyG-WC). The study found that compared with the first quintile (Q1), TyG-BMI, TyG-WC, and TyG-WHtR of the second–third quintiles (Q2) and fourth–fifth quintiles (Q3) were significantly associated with psoriasis. Furthermore, the authors conducted subgroup analyses of the relationship between the three TyG indices and psoriasis based on all covariates, revealing that most covariates did not exhibit interaction effects. We acknowledge the valuable contributions made by the authors; however, we still have some questions regarding this study.
Statistical methods
In the statistical analysis, the authors stated that they used multivariate logistic regression to examine the associations between the three TyG-related indices and psoriasis. However, since psoriasis is a binary outcome variable, it appears the authors may have conflated multivariate logistic regression with binary logistic regression. To enhance the rigor and accuracy of the study, we recommend revising the statistical analysis to specify the use of binary logistic regression. Additionally, the article notes that data with missing covariates were directly excluded. The authors should clarify the reasons for excluding participants due to missing covariates to ensure that selection bias was not introduced. In the subgroup analysis, the authors stated that there was no interaction between TyG-BMI and hypertension or hypertriglyceridemia (p for interaction > 0.05). However, this assertion appears to be inaccurate, as Figure 3 clearly demonstrates that the relationship between TyG-BMI and psoriasis is influenced by hypertension (p for interaction < 0.001). We believe this error should be corrected to prevent potential misinterpretation by readers.
Covariate selection
The article has commendably incorporated covariates such as age, sex, race, education, smoking history, alcohol consumption, hypertension history, and diabetes history. However, given that numerous studies have shown physical activity can improve disease outcomes in patients with psoriasis (2), and that psoriasis imposes a long-term and substantial economic burden on patients and their families (3), we strongly recommend that the authors include physical activity and household income as additional covariates in their analysis.
Assessment of predictive capacity
The final conclusion of this study states that TyG-related indices (TyG-BMI, TyG-WC, and TyG-WHtR) exhibit a stable and strong positive correlation with psoriasis. However, this conclusion may leave readers with the impression that the research is incomplete. For example, it remains unclear how these three TyG-related indices compare in terms of diagnostic capability for psoriasis. Therefore, we encourage the authors to incorporate a combined diagnostic test analysis to evaluate and compare the diagnostic performance of TyG-BMI, TyG-WC, and TyG-WHtR, which would be more helpful in guiding clinical practice.
Discussion
Overall, this is a highly instructive study for clinical practice. To ensure that the research objectives are conveyed more accurately and comprehensively, we hope the authors will address the issues we have raised. We also believe this study will offer valuable insights into the prevention and management of psoriasis.
Statements
Author contributions
PS: Methodology, Supervision, Writing – review & editing. BN: Formal analysis, Methodology, Writing – original draft. BL: Formal analysis, Supervision, Writing – review & editing.
Funding
The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by the project titled “Investigating the mechanism of the Kaixuan Jiedu core formula in treating psoriasis complicated by hypertriglyceridemia via the NRF1/TFAM signaling axis-mediated mitochondrial biogenesis” (No. 82474521).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Generative AI statement
The author(s) declare that no Generative AI was used in the creation of this manuscript.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1
Huang D Ma R Zhong X Jiang Y Lu J Li Y et al . Positive association between different triglyceride glucose index-related indicators and psoriasis: evidence from NHANES. Front Immunol. (2023) 14:1325557. doi: 10.3389/fimmu.2023.1325557
2
Zhu H Sun Q Choi H Li Y Zhang W . Association of psoriasis disease with physical activity and exercise: systematic review and meta-analysis. Postepy Dermatol Alergol. (2024) 41:450–5. doi: 10.5114/ada.2024.143424
3
Sanclemente G Mora O Velez N Diaz CJ Quevedo E Amador J et al . Epidemiologic characteristics and burden of psoriasis: A multicenter, cross-sectional study. Medwave. (2022) 22:e002564. doi: 10.5867/medwave.2022.08.002564
Summary
Keywords
National Health and Nutrition Examination Survey (NHANES), psoriasis, triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist to height ratio (TyG-WHtR), and triglyceride glucose-waist circumference (TyG-WC)
Citation
Ning B, Li B and Song P (2025) Commentary: Positive association between different triglyceride glucose index-related indicators and psoriasis: evidence from NHANES. Front. Immunol. 16:1580061. doi: 10.3389/fimmu.2025.1580061
Received
21 February 2025
Accepted
24 April 2025
Published
09 May 2025
Volume
16 - 2025
Edited by
Jie Li, Central South University, China
Reviewed by
Dimitrios Kehagias, University of Patras, Greece
Updates
Copyright
© 2025 Ning, Li and Song.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Ping Song, songping_cacms@163.com
†These authors have contributed equally to this work
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.