SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1580405
This article is part of the Research TopicImmune-Cancer Cell InteractionView all 5 articles
Bibliometric and Visual Analysis of Global CRC Circular RNA Research 2015-2023
Provisionally accepted
- medical postgraduate, Zunyi, China
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colorectal cancer (CRC) is the third highest malignant tumor in the world in terms of incidence rate, accounting for about 10% of all cancer cases and the second leading cause of cancer related deaths. Timely diagnosis and effective treatment are key to significantly improving the survival rate of CRC patients. Various factors including gender, environmental factors, lifestyle choices, and genetic predisposition are all causes of the onset of CRC. Circular RNA(circRNA) mainly exists in cancer cells and tissues, solid tumors, peripheral blood, exosomes, and body fluids (such as serum, plasma, and saliva). Due to their resistance to degradation and presence in body fluids, CircRNA is non-invasive and an ideal candidate for liquid biopsy, thus having high diagnostic potential. Current research has found that circRNA can regulate the proliferation, migration, invasion, and apoptosis of CRC cells. This article aims to comprehensively evaluate the current status and trends of circRNA research in the field of CRC through bibliometric analysis. Intended to use software tools such as VOSviewer, CiteSpace, Microsoft Excel, and R language package to illustrate research progress and focus, in order to outline development trends and future research directions. This study used specific inclusion and exclusion criteria to investigate 1048 papers published before December 31, 2023 in the core database of the World Council for Scientific Knowledge. Our research findings indicate that China has the highest number of published papers in this field, with Nanjing Medical University and Kiavash Hushmandi considered the most influential institutions and authors. The Journal ofOncology Frontiers is the journal with the most published papers, while the article "Circular RNA: The New Star of Non coding RNA" is the journal with the most published papers. In addition, terms such as "signaling pathway", "promoting metastasis", "promoting proliferation", and "drug resistance" have become important focuses in this research field.
Keywords: circular RNA, CRC, review, bibliometric analysis, visualisation analysis, Citespace, VOSviewer
Received: 20 Feb 2025; Accepted: 26 May 2025.
Copyright: © 2025 Bin, Chen, wang, Ge and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hua Ge, medical postgraduate, Zunyi, China
Wei Chen, medical postgraduate, Zunyi, China
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